Results 71 to 80 of about 33,085,515 (346)
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Monitoring Pipeline Leaks Using Fractal Analysis of Acoustic Signals
Fractal and FractionalThis paper proposes a method for searching for pipeline leaks by analyzing the Hurst exponent of acoustic signals. The investigations conducted on the laboratory setup and the current pipelines of the water supply system.
Ayrat Zagretdinov +5 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Detection of Pipeline Leaks Using Fractal Analysis of Acoustic Signals
Fractal and FractionalIn this paper, the possibility of using monofractal and multifractal analysis of acoustic signals of pipelines to detect leaks is considered. An experimental stand has been created to study the fractal characteristics of acoustic signals of pipelines ...
Ayrat Zagretdinov +5 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Power Optimization of Multi-fluid Transportation Systems [PDF]
, 1990 6th IFAC/IFIP/IFORS/ IMACS Symposium on Information Control Problems in Manufacturing Technology, 26/09/1989. madrid.This paper presents an algorithm for optimizing the energy operating costs in multi-fluid transportation systems.
Camacho, Eduardo F. +2 more
core
Recent Advances in Computational Methods for the Power Flow Equations [PDF]
, 2015 The power flow equations are at the core of most of the computations for designing and operating electric power systems. The power flow equations are a system of multivariate nonlinear equations which relate the power injections and voltages in a power ...
Mehta, Dhagash +2 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source