Results 81 to 90 of about 502,978 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Industrialization in Pakistan A case of Frustrated take-Off ?
, 1963 Development planning in Pakistan aims at reaching the stage of self generating growth "within a measurable period of time"1. The perspective of long-term growth outlined in the Second Five Year Plan envisages a quad¬rupling of national ...
Power, John H.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 1995 The Power Take Off (PTO) Drive, found on most farm tractors, is a major power source for agricultural equipment. The PTO system efficiently transfers mechanical power from the tractor to the implement, but it may present serious hazards to persons who ...
Hallman, Eric, Demmin, Darcy M.
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Wave-actuated power take-off device for electricity generation [PDF]
, 2013 Since 2008, Resolute Marine Energy, Inc. (RME) has been engaged in the development of a rigidly moored shallow-water point absorber wave energy converter, the "3D-WEC".
Chertok, Allan
core
Evidence of the trade-off between starvation and predation risks in ducks
, 2011 The theory of trade-off between starvation and predation risks predicts a decrease in body mass in order to improve flight performance when facing high predation risk.
Zimmer, Cedric +22 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Off Peak Power - An Alternative to Interruptible Service
, 1984 Georgia Power's Off-Peak Rider encourages load reductions up to 40% during on-peak periods over four summer months each year. Since summer on-peak time represents about 50% of available time, the customer's productive summer capacity may be reduced 20 ...
Nordyke, H. G., Jr.
core