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Abstract 3999: Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors

Cancer Research, 2023
Background: Trastuzumab deruxtecan (T-DXd) has been approved for advanced or metastatic breast, gastric and lung cancers. It has been postulated that irreversible tyrosine kinase inhibitors (TKIs) increase HER2 internalization, thus enhancing T-DXd ...
D. Bhavsar   +12 more
semanticscholar   +1 more source

Abstract 3999: HLA-G, SPAG9 and STAT3 signalling: An alliance that promotes early-stage brain metastases

Cancer Research, 2022
Brain metastases (BM) are the most common brain tumours in adults and a prominent cause of cancer-related mortality globally. Leading sources of BM are cancers of the lung, breast and melanoma, which together account for approximately 80% of all BM ...
B. Bassey-Archibong   +12 more
semanticscholar   +1 more source

Autocitação na Ciência da Informação no Brasil estudo bibliométrico com pesquisadores PQ1 (2004-2021)

Anais do 9º Encontro Brasileiro de Bibliometria e Cientometria - EBBC
Analisa o comportamento de autocitação dos pesquisadores bolsistas de Produtividade em Pesquisa nível 1 da área da Ciência da Informação. Avalia diacronicamente a intensidade das autocitações nos artigos publicados de 2004 a 2021, por sexsênio e ...
Jéssyca Rodrigues Henrique da Silva   +2 more
semanticscholar   +1 more source

Abstract 3999: Augmentation of antitumor effects by CAR-T cells secreting anti-PD-1 single-chain antibody fused with IL-21

Cancer Research
Background: Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematologic malignancies. However, many patients suffer from limited response and tumor relapse due to lack of persisting CAR-T cells and immune escape ...
Ying Li   +6 more
semanticscholar   +1 more source

Wonders beyond numbers: a brief history of all things mathematical by Johnny Ball, pp. 480, £16.99 (hard), ISBN 978-1-4729-3999-9, Bloomsbury Sigma (2017).

Mathematical Gazette, 2019
The number of potentially tricky concepts the book seeks to cover is impressive. The reader will encounter imaginary numbers, matrices, calculus, formal logic, topology, group theory, non-Euclidean geometry and considerably more besides, along the ...
P. Giblin
semanticscholar   +1 more source

Desuspensions of S1 ∧ (ℙℚ1 −{0,1,∞})

, 2016
We use the Galois action on π1et(ℙ Q¯1 −{0, 1,∞}) to show that the homotopy equivalence S1 ∧ (𝔾 m,ℚ ∨ 𝔾m,ℚ)≅S1 ∧ (ℙ ℚ1 −{0, 1,∞}) coming from purity, does not desuspend to a map 𝔾m,ℚ ∨ 𝔾m,ℚ → ℙℚ1 −{0, 1,∞}.
K. Wickelgren
semanticscholar   +1 more source

Abstract 3999: Advanced lung adenocarcinoma cell bank (ALACB) : A comprehensive preclinical platform

Clinical research, 2019
Purpose: Patients with advanced lung adenocarcinoma often lack large clinical specimens required for molecular testing which limits next therapeutic options.
Hyeong-Seok Joo   +7 more
semanticscholar   +1 more source

Abstract 3999: Single cell transcriptomic comparison of patient derived ovarian cancer organoids and primary tumor epithelial signatures

Cancer Research
High-grade serous ovarian cancer (HGSOC) is a rare but deadly disease. Platinum-based therapy along with PARPi maintenance therapy, is recommended to 80% of patients.
Bisiayo Fashemi   +5 more
semanticscholar   +1 more source

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