Results 91 to 100 of about 1,678,179 (242)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Modèle de prédiction de la dégradation des matériaux polymères en milieu réel

Sciences, Eaux & Territoires, 2000
Le développement de polymères biodégradables, pour l'emballage et les produits d'usage courant a pris un intérêt considérable. Cependant, dire qu'un matériau est biodégradable nécessite d'évaluer son taux de biodégradabilité. L'objectif de ce travail est
A. CALMON, F. SILVESTRE, V. BELLON-MAUREL, P. FEUILLOLEY   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Prédiction par modélisation phylogénétique de morphologies ancestrales du fémur chez les hominines

Bulletins et Mémoires de la Société d’Anthropologie de Paris, 2023
Hugo Hautavoine, Aurélien Mounier, Gilles Berillon   +2 more
doaj   +1 more source

Prédiction linéaire et principe de l'entropie maximale. Première partie Linear Prediction and the Maximum Entropy Principle. Part One

Oil & Gas Science and Technology, 2006
La prédiction linéaire est de nos jours de plus en plus utilisée et dans des domaines très variés : démographie, économie, météorologie, analyse du signal, . . .
Bois P.
doaj   +1 more source

Prédictions d'activité dans les réseaux sociaux en ligne

, 2013
National audienceOnline Platforms dedicated to social networking host new social phenomenons. Thus several keywords may suddenly take an unprecedented importance, reflecting the number of dis- cussions they have raised within a short time period.
Dimert, Eustache, Douzal-Chouakria, Ahlame, Gaussier, Eric, Kawala, François   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Prédiction numérique de l’écoulement turbulent autour des pales d’une éolienne à axe horizontal

Revue des Énergies Renouvelables, 2010
Ce papier présente une méthode de simulation numérique pour la prédiction d’écoulement autour d’une éolienne à axe horizontal opérant en régime stationnaire, en utilisant le code ‘Fluent’.
R. Hamel, A. Smaïli
doaj  

Revisiting the Status of Speech Rhythm [PDF]

, 2002
Text-to-Speech synthesis offers an interesting manner of synthesising various knowledge components related to speech production. To a certain extent, it provides a new way of testing the coherence of our understanding of speech production in a highly ...
Zellner Keller, Dr. Brigitte
core   +1 more source