Results 131 to 140 of about 1,678,179 (242)
Protein Structural Annotation: Multi-task learning and feature selection [PDF]
, 2014 Experimentally determining the three-dimensional structure of a protein is a slow and expensive process. Nowadays, supervised machine learning techniques are widely used to predict protein structures, and in particular to predict surrogate annotations ...
Becker, Julien
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Prise en charge des troubles de la communication : La Plateforme de Communication Alternative
, 2008 International audienceWe present in this paper an alternative communication system for handicapped persons. Alternative communication primarily relies on an alternative access to the computer and has to take into account the communication situation ...
Ader, Morgane +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Revue des Sciences Humaines, 2001 L’éducateur sportif comme le théoricien s’attachent à comprendre ce qu’il y a de fluctuant dans la nature de la pratique sportive. Par le biais de la lecture du jeu et dans un souci de mieux maîtriser certains invariants, ils tentent de systématiser ...
A BOUARRATA
doaj
, 2002 Un programme de mesures des propriétés de rétention en eau des sols a été développé par l'INRA depuis une dizaine d'années afin de constituer un jeu de données qui puisse être utilisé pour tester les fonctions de pédotransfert (FPT) qui ont été proposées
Bruand, Ary +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source