Results 81 to 90 of about 2,588,504 (198)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Evaluation de niveau de connaissances, d’attitudes et pratiques de prévention de la population de Wangata à l’Equateur en République démocratique du Congo face à l’épidémie de Monkeypox en 2025.

Revue des Sciences de la Santé
Le MPOX constitue un problème persistant de santé publique en République démocratique du Congo, particulièrement dans la province de l’Equateur où l’impact socio-sanitaire demeure préoccupant.
Roger MOLALA BONDOKO, Bernard NTOTO KUNZI, MUKANDU BASUA BASANTU LEYKA   +2 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Prévalence de la paralysie flasque aigue et surveillance environnementale des poliovirus à Kinshasa en République Démocratique du Congo.

Revue des Sciences de la Santé
La poliomyélite demeure un problème de santé publique malgré les progrès liés à la vaccination, en raison de la persistance des poliovirus dérivés de souches vaccinales, particulièrement dans les zones à faible couverture vaccinale.
Jimmy LIGAMBA BALE, Narcisse YOGOLELO RIZIKI, Odile FALANKA AYIWAB, Balthazar PHOBA PHOBA, Albert BUSHABU KONGO, Jean Pierre BASILUA KANZA, Colette ASHANDE MASENGO, Jean Paul IYOMBE ENGEMBE   +7 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Clinical and Epidemiological Profile of Chronic Kidney Disease in Patients with Type 2 Diabetes in Cameroon

Health Research in Africa
Introduction. Despite chronic kidney disease (CKD) being a major problem in Type 2 diabetes mellitus (T2DM), only a few studies have addressed CKD among patients with T2DM in Cameroon. The aim of our study is to determine the clinical and epidemiological
Teuwafeu Denis Georges, Mbeleg Madeleine Dorcas Ornella, Ronald Gobina Mbua, Mafouk Fopa Dianna Fontania, Tsague syntiche, Balepna Jean Yves, Ivan Nkeng, Folong Kamta, Halle Marie-Patrice   +8 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Prévalence des infections urinaires chez les personnes vivant avec le VIH/Sida à l’Hôpital Général de Référence de Bunia, Province de l’Ituri en République démocratique du Congo.

Revue des Sciences de la Santé
Cette recherche vise à analyser la prévalence et les caractéristiques des infections urinaires (IU) chez les personnes vivant avec le VIH (PVVIH), ainsi qu'à identifier les facteurs sociodémographiques, cliniques et comportementaux qui y sont associés ...
Liévin TIBASIMA DHESSA, Yannick JOBALO MATATA, Didy ONAUTSHU ODIMBA, Denis KANDOLO KAKONGO   +3 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source