Results 161 to 170 of about 2,327,140 (248)

Forest Fires and the Law:A Guide for National Drafters based on the Fire Management Voluntary Guidelines [PDF]

, 2009
Cirelli, Maria Teresa, Morgera, Elisa
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Impact of Real-Time Data Analytics on Infection Prevention and Control Practices in Ophthalmology: A Nursing Perspective on Patient Outcomes and Cost-Effectiveness. [PDF]

Nurs Health Sci
Chen Z, Wu S, Zhou Y, Tang C.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Translational Needs: Informing Tools to Close the Knowledge-to-Practice Gap in Suicide Prevention. [PDF]

Health Promot J Austr
Tran M, Stewart L, Cuenca J, Benson M, Reifels L.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Regional Inequalities in Trachoma Prevention in Ethiopia: A Meta-Analysis. [PDF]

Health Sci Rep
Asmare ZA, Yeshiwas AG, Bayeh GM, Tsega TD, Tsega SS, Gebeyehu AA, Yemata GA, Anteneh RM, Ejigu AG, Ahmed AF, Yigzaw ZA, Temesgen A, Kebede AM, Mekonen H, Enawgaw AS, Yirdaw G, Mekonnen BA, Alemayehu MA, Gashu ZE, Yenew C.   +19 more
europepmc   +1 more source

Réunion du comité de pilotage du réseau régional de santé animale CaribVET et atelier influenza aviaire, Trinité et Tobago, avril 2006 [PDF]

, 2006
CIRAD-EMVT - FRA
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Trends and inequalities in statin use for the primary and secondary prevention of cardiovascular disease between 2009 and 2021 in England: a series of cross-sectional and cohort studies. [PDF]

BMJ Public Health
Muzambi R, Bhaskaran K, Strongman H, van Staa T, Smeeth L, Suffel AM, Herrett E.   +6 more
europepmc   +1 more source