Results 41 to 50 of about 2,300,230 (246)
Trayectorias Humanas Trascontinentales, 2019 Les dispositifs PEAMA en Colombie et DAEU en France relatifs au décrochage scolaira sont étudiés à partir des lois politiques éducatives qui les impulsent jusqu’à leur mise en œuvre au quotidien des acteurs.
Adriana Patricia Silva Hernández +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Regard éthique et critique sur la seconde édition du Sommet de la santé durable
Canadian Journal of BioethicsLes 30 et 31 janvier 2024, la seconde édition du Sommet de la santé durable, organisée par l’Association pour la santé publique du Québec, a eu lieu, et ce, simultanément à Québec et à Montréal.
Valérie Lafond +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
E3S Web of Conferences, 2016 French law on major risk preventive information for population setup the objective to make the citizen able to act for his own safety and to participate through his behaviour to the civil security.
Jadot Julien +3 more
doaj +1 more source
Trayectorias Humanas Trascontinentales, 2018 Aujourd’hui, l’engagement de personnes dans un radicalisme violent, politique ou religieux, menace la sécurité publique. Pour contribuer à solutionner ces problèmes transcontinentaux, plusieurs pays ont mis en œuvre des programmes de prévention primaire ...
Hélène HAGEGE, Mohammed EL OURMI
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Glossa, 2023 Contexte : De plus en plus d’enfants sont inscrits dans des crèches. Dans ces structures, le soutien au développement langagier des enfants est un enjeu majeur, notamment pour l’accès aux futurs apprentissages scolaires.
Camille Moitel Messara +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source