Results 81 to 90 of about 1,055,290 (365)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Correlation between levels of physical activity, disease severity and pain intensity in women with fibromyalgia

BrJP
BACKGROUND AND OBJECTIVES: Currently, there is conflicting evidence regarding both physical activity and exercise in relation to the impact of fibromyalgia (FM).
Márcio Bruning, Jonato Prestes, Nuno Manuel Frade de Sousa, Gabriel Caetano Pereira, Fernanda Maria Borghi, Leonardo Pestillo de Oliveira   +5 more
doaj   +1 more source

Risk and protective factors for non communicable diseases in the Belo Horizonte population: Vigitel 2008

Revista Brasileira de Epidemiologia, 2013
Introduction: The Non Communicable Diseases (NCD) are the main causes of death in, having known, avoidable the Risk Factor (RF) and susceptible to intervention.
Bruna Mara Duarte, Regina Tomie Ivata Bernal, Deborah Carvalho Malta   +2 more
doaj   +1 more source

Stakeholder management through relationship management [PDF]

, 2010
postprin
Koh, TY, Rowlinson, SM, Tuuli, MM
core  

Impact of Latest Technology in Mandalika MotoGP Tourism PR: SWOT Review

INTERNATIONAL JOURNAL OF ECONOMICS, MANAGEMENT, BUSINESS, AND SOCIAL SCIENCE (IJEMBIS)
This study explores the integration of digital technology in tourism promotion, focusing on the transformative impact of social media, AI, and big data. Using qualitative methods and SWOT analysis, the paper discusses the challenges and opportunities in ...
D. Awaloedin, Gagih Pradini, Yohana Gaius Bule, Davi Ayu Andini   +3 more
semanticscholar   +1 more source

Chemical Synthesis and biochemical reactivity of bacterlophage bambda p_Rpromoter [PDF]

Nucleic Acids Research, 1983
By a combination of chemical and enzymatic methods, a 75 base pair DNA duplex containing the sequence of the lambda PR promoter including the OR1 and OR2 cI repressor binding sites was synthesized. The solid support phosphite triester procedure (Caruthers, M. H.
P L, deHaseth, R A, Goldman, C L, Cech, M H, Caruthers   +3 more
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Integrated analysis of the role of PR/SET domain 14 in gastric cancer

BMC Cancer
Gastric cancer is one of the most common tumors worldwide, and most patients are deprived of treatment options when diagnosed at advanced stages. PRDM14 has carcinogenic potential in breast and non-small cell lung cancer.
Xiao Li, Cong Wang, Youcai Wang, Xiaobing Chen, Zhi Li, Jianwei Wang, Yingjun Liu   +6 more
semanticscholar   +1 more source

Rho-dependent termination of transcription. II. Kinetics of mRNA elongation during transcription from the bacteriophage lambda PR promoter.

Journal of Biological Chemistry, 1983
The kinetics of elongation of the mRNA that initiates from the lambda PR promoter has been examined using specific restriction fragments as template, and the locations at which significant pausing of the RNA polymerase occurs during in vitro transcription have been established.
W D, Morgan, D G, Bear, P H, von Hippel
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source