Results 101 to 110 of about 745,731 (317)

Factors associated with oral frailty among community-dwelling older adults in Chengdu, China: a cross-sectional study

open access: yesBMC Geriatrics
Background This study aims to reveal the factors associated with oral frailty among community dwelling older adults in Chengdu, China. Methods A community-based cross-sectional study was conducted. Oral frailty was assessed using the Oral Frailty Index-6,
Sikai Tang   +7 more
doaj   +1 more source

Exploration of evaluation criteria based on the biological variation in the external quality assessment for basic semen analysis in China

open access: yesAsian Journal of Andrology
This study explores whether the current external quality assessment (EQA) level and acceptable bias for basic semen analysis in China are clinically useful.
Xi-Yan Wu   +8 more
doaj   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

open access: yesAdvanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu   +20 more
wiley   +1 more source

A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients

open access: yesJournal of Inflammation Research
Shan Chen,1,* Wan-Hua Chang,2,* Jie Zhang,1,* Xiao-Yuan Liu,3,* Ting Gao,1 Xiao-Wei Qi,4 Dong-Yan Cai,1 Yong Mao,1 Ting-Xun Lu1 1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic
Chen S   +8 more
doaj  

A survey on mental health among resident physicians: psychological resilience as a mediator

open access: yesBMC Psychiatry
Background Sleep disturbances (SD) among resident physicians have been shown to negatively impact their mental health, potentially leading to suicidal ideation (SI) and reduced life satisfaction (LS).
Yunjuan He   +7 more
doaj   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang   +16 more
wiley   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao   +13 more
wiley   +1 more source

Proficiency testing of diagnosis in histopathology and immunohistochemistry of breast pathology in China: results from a pilot work of National Single Disease Quality Control Program for breast cancer

open access: yesBMC Cancer
Aim Pathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how successfully these guidelines have been integrated into routine clinical practice in China.
Xuemin Xue   +17 more
doaj   +1 more source

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