Results 121 to 130 of about 4,441,566 (351)

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Physicians’ Knowledge of Pulmonary Rehabilitation in China: A Cross-Sectional Study

International Journal of COPD
Feng Pan,1,* Ai-ting Lu,1,2,* Xiaowei Mao,1,* Fang Hu,1 Hai Zhang,1 Baohui Han1 1Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China; 2Department of Pulmonary and ...
Pan F, Lu AT, Mao X, Hu F, Zhang H, Han B   +5 more
doaj  

China–Burma Geopolitical Relations in the Cold War

Journal of Current Southeast Asian Affairs, 2012
This paper explores the historical role of geography in the Sino–Burmese relationship in the context of the Cold War, both before and after the Chinese–American détente and rapprochement in the 1970s.
Hongwei FAN
doaj  

A survey on mental health among resident physicians: psychological resilience as a mediator

BMC Psychiatry
Background Sleep disturbances (SD) among resident physicians have been shown to negatively impact their mental health, potentially leading to suicidal ideation (SI) and reduced life satisfaction (LS).
Yunjuan He, Shengnan Lin, Yixuan Wang, Bo Zhang, Yifan Wang, Shouqin Sheng, Xinlong Gu, Wenyan Wang   +7 more
doaj   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients

Journal of Inflammation Research
Shan Chen,1,* Wan-Hua Chang,2,* Jie Zhang,1,* Xiao-Yuan Liu,3,* Ting Gao,1 Xiao-Wei Qi,4 Dong-Yan Cai,1 Yong Mao,1 Ting-Xun Lu1 1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic
Chen S, Chang WH, Zhang J, Liu XY, Gao T, Qi XW, Cai DY, Mao Y, Lu TX   +8 more
doaj  

Proficiency testing of diagnosis in histopathology and immunohistochemistry of breast pathology in China: results from a pilot work of National Single Disease Quality Control Program for breast cancer

BMC Cancer
Aim Pathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how successfully these guidelines have been integrated into routine clinical practice in China.
Xuemin Xue, Lei Guo, Changyuan Guo, Lin Li, Lin Yang, Xin Wang, Wei Rao, Pei Yuan, Jiali Mu, Jiangtao Li, Bingning Wang, Quan Zhou, Wentao Yang, Yueping Liu, Weicheng Xue, Rujing Jia, Wenjing Yang, Jianming Ying   +17 more
doaj   +1 more source

WAYS OF FORMING PRIMARY SCHOOL TEACHERS-TO-BE PROFESSIONAL COMPETENCE IN MODERN PR CHINA

, 2021
Peng Chen
openalex   +2 more sources

Tumor‐Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells

Advanced Science, EarlyView.
This study demonstrates that tumor‐derived IL‐35 promotes pancreatic cancer fibrosis by indirectly activating pancreatic stellate cells through IGFBP2/IGF‐1R/PI3K‐Akt and Tsp‐1/TGF‐β pathways. IL‐35 blockade reduces stromal fibrosis, restores chemosensitivity, and synergizes with gemcitabine‐based regimens, highlighting IL‐35 as a promising therapeutic
Hui Li, Huizhi Sun, Jing Liu, Yan Wu, Lin Wei, Jianming Li, Yudong Yuan, Peng Xie, Chao Xu, Guolu Luo, Yuqi Guan, Yukuan Feng, Antao Chang, Jihui Hao, Chongbiao Huang   +14 more
wiley   +1 more source