Results 181 to 190 of about 745,731 (317)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu   +9 more
wiley   +1 more source

Nursing Future Horizon: Simultaneous Continual Nursing Model and Homemade Dialogue Tool for Controlling Cardiac Function and Blood Pressure in Hypertensive Heart Diseases

open access: yesPatient Preference and Adherence
Hai Ou Yang,1 Aiping Wang,2 Haihua Hu,3 Yue Li4 1Beijing Tongren Hospital Affiliated to Capital Medical University, PR. China Internal Medicine Department 100730, Beijing, People’s Republic of China; 2Beijing Tongren Hospital Affiliated to Capital ...
Yang HO, Wang A, Hu H, Li Y
doaj  

Integration of Freestanding High‐k Oxide Membranes for 2D Ferroelectric Field‐Effect Transistors

open access: yesAdvanced Science, EarlyView.
This work introduces a defect‐tolerant integration strategy that enables freestanding BaTiO3 membranes to form low‐leakage top‐gate junctions with MoS2. The resulting FeFETs exhibit a record 0.22 V nm−1 memory window, ultrahigh‐k response, and near‐ideal subthreshold swings.
Zejing Guo   +16 more
wiley   +1 more source

TCMLLM-PR: evaluation of large language models for prescription recommendation in traditional Chinese medicine

open access: diamond
Tian Haoyu   +11 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

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