Results 191 to 200 of about 4,441,566 (351)

Breath, Pulse, and Speech: A Multi‐Parameter Wearable System using Airflow‐Thermoelectric Fusion Technology

open access: yesAdvanced Science, EarlyView.
For insufficient medical emergency monitoring, this study develops a wearable system with flexible thermoelectric textiles and thermoelectric‐optical sensing. It establishes a dynamic airflow‐thermoelectric response theory (enabling 98% speech recognition) and a multi‐source fusion model for 98% emergency state recognition, aiding clinical decision ...
Zheng Zhu   +10 more
wiley   +1 more source

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

open access: yesAdvanced Science, EarlyView.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang   +17 more
wiley   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang   +12 more
wiley   +1 more source

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