Results 81 to 90 of about 745,731 (317)

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

open access: yesAdvanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao   +13 more
wiley   +1 more source

Long‐Term Active Rather than Passive Restoration Promotes Soil Organic Carbon Accumulation by Alleviating Microbial Nitrogen Limitation in an Extremely Degraded Alpine Grassland

open access: yesAdvanced Science, EarlyView.
Active restoration increases soil organic carbon stocks by reducing microbial nitrogen limitation. Nitrogen availability promotes particulate to mineral‐associated organic carbon conversion by reducing microbial carbon use efficiency. Passive restoration has no effect on soil organic carbon stocks.
Jinchao Gong   +15 more
wiley   +1 more source

Determinants and structural development of FDI in Pacific-Rim developing countries [PDF]

open access: yes
The movements of foreign direct investment (FDI) in the recent past are marked by a relatively very high growth in the Pacific Rim (PR) countries (Australia, Brunei, China, Hongkong, Japan, Indonesia, Malaysia, Papua New Guinea, New Zealand, Philippines,
Agarwal, Jamuna Prasad
core  

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

open access: yesAdvanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

open access: yesAdvanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen   +11 more
wiley   +1 more source

Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system.

open access: yesPLoS ONE, 2019
ObjectiveTo describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies.MethodsData were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007-2014.
Ling Yi   +10 more
doaj   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

open access: yesAdvanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng   +20 more
wiley   +1 more source

БНМАУ, ЗСБНХУ ба БНХАУ-ын хооронд төмөр замын шууд харилцаа байгуулах тухай хэлэлцээр

open access: yesОлон улс судлал, 2014
English title: Agreement on establishment of direct railway between the PR of Mongolia, the USSR and PR of ...
doaj  

Serum BICC1 levels are significantly different in various mood disorders

open access: yesNeuropsychiatric Disease and Treatment, 2019
Suzhen Chen,1,2 Haitang Jiang,1,2 Zhi Xu,1,2 Jingjing Zhao,3 Ming Wang,4 Yan Lu,5 Jianhua Li,6 Fei Sun,7 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China ...
Chen S   +8 more
doaj  

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