Results 151 to 160 of about 987,544 (291)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Analysis of Peripheral T Cell Profiling and Plasma Proteomics in Advanced NSCLC Patients Treated With Atezolizumab

Cancer Science, EarlyView.
This study found immune markers that may predict how well patients with advanced lung cancer respond to atezolizumab. Higher levels of certain T cells were linked to better survival. Specific patterns suggested a worse prognosis for some patients. ABSTRACT We investigated immunologic biomarkers that predict outcomes of patients with previously treated ...
Atsuto Mouri, Hiroshi Kagamu, Koji Tamada, Makoto Nishio, Hiroaki Akamatsu, Yasushi Goto, Hidetoshi Hayashi, Satoru Miura, Akihiko Gemma, Ichiro Yoshino, Toshihiro Misumi, Ryota Saito, Noriko Yanagitani, Fujita Masaki, Hiroshi Nokihara, Kazumi Nishino, Masahiro Seike, Tetsunari Hase, Osamu Hataji, Hiroaki Takeoka, Yosuke Kawashima, Hirotaka Kuroki, Masamichi Sugimoto, Hiroshi Kuriki, Tetsuya Mitsudomi   +24 more
wiley   +1 more source

Four‐Year Outcomes for Nivolumab With Chemotherapy and Bevacizumab in Patients With Nonsquamous NSCLC in the TASUKI‐52

Cancer Science, EarlyView.
This follow‐up study for TASUKI‐52 trial demonstrates the 4‐year beneficial efficacy of nivolumab (NIV) combined with chemotherapy (CP) and bevacizumab (BEV) in patients with nonsquamous non‐small cell lung cancer (NSCLC) and reveals potential patient backgrounds associated with long‐term survival.
Jong‐Seok Lee, Shunichi Sugawara, Jin‐Hyoung Kang, Hye Ryun Kim, Naoki Inui, Toyoaki Hida, Ki Hyeong Lee, Tatsuya Yoshida, Hiroshi Tanaka, Cheng‐Ta Yang, Takako Inoue, Makoto Nishio, Yasushi Goto, Tomohide Tamura, Nobuyuki Yamamoto, Chong‐Jen Yu, Hiroaki Akamatsu, Shigeru Takahashi, Kazuhiko Nakagawa   +18 more
wiley   +1 more source

Overlap of nonbreeding wandering albatrosses with fisheries and implications for colony‐specific population trajectories at South Georgia

Conservation Biology, EarlyView.
Abstract Bycatch in fisheries is one of the most serious threats to pelagic seabirds, causing major population declines. Mitigation measures can reduce bycatch substantially, but many fisheries fail to apply best practices, and seabird mortality remains high.
V. Warwick‐Evans, E. J. Pearmain, R. A. Phillips   +2 more
wiley   +1 more source

Experiência de famílias e terapeutas com um programa de telessaúde para crianças e adolescentes com paralisia cerebral durante a pandemia de COVID‐19

Developmental Medicine &Child Neurology, EarlyView.
Experiências de pais de crianças com paralisia cerebral e terapeutas no programa individualizado. Resumo Objetivo Compreender as percepções das famílias e terapeutas sobre a sua participação em um programa domiciliar individualizado via telessaúde implementado para crianças e adolescentes com paralisia cerebral (PC) durante a pandemia da COVID‐19 no ...
Rachel Oliveira, Marisa Mancini, Priscilla Figueiredo, Katia Bueno, Andrew M. Gordon, Marina Brandão   +5 more
wiley   +1 more source

Political risk assessment in the Czech Republic [PDF]

This paper seeks to conceptualise a new approach to the identification of the factors influencing the adoption of a political risk assessment (PRA) function. The research population will comprise a convenience sample of Czech international firms.
Anchor, J.R, Benesova, Hana
core  

Assessing the Progress of Stock Rebuilding in the Northeast Atlantic Against Levels That Can Produce Maximum Sustainable Yield

Fish and Fisheries, EarlyView.
ABSTRACT Rebuilding fish stocks to levels above which they produce Maximum Sustainable Yield (MSY) is a management aim for all European commercially exploited stocks. Progress is typically monitored against the fishing mortality that produces MSY in the long term (FMSY), however, the corresponding biomass target (BMSY) is rarely evaluated nor reported.
Henning Winker, Massimiliano Cardinale, Rishi Sharma, Laurence T. Kell, Iago Mosqueira, Christopher Griffiths   +5 more
wiley   +1 more source

Pra Mimbar

Mimbar, 2009
Pra ...
Dewan Redaksi Mimbar
doaj  

"Making Safety Happen" Through Probabilistic Risk Assessment at NASA [PDF]

NASA is using Probabilistic Risk Assessment (PRA) as one of the tools in its Safety & Mission Assurance (S&MA) tool belt to identify and quantify risks associated with human spaceflight. This paper discusses some of the challenges and benefits associated
Berrios, Alfred S., Boyer, Roger L., Cross, Robert B., Grant, Warren C., Hamlin, Teri L., Rogers, James H., Stewart, Michael A.   +6 more
core   +1 more source

High Cost and Low Trust: Insights From Qualitative Commercial Fishing Cost Data in the Northeast United States

Fisheries Management and Ecology, EarlyView.
ABSTRACT In fisheries management, socioeconomic data, specifically qualitative data analysis, is often underutilized. This study qualitatively analyzed a primary federal data collection effort in the Northeast United States, The Greater Atlantic Region Commercial Fishing Business Cost Survey.
Elizabeth D. Conley, Samantha Werner, Gregory Ardini, Matthew Cutler, Patricia M. Clay   +4 more
wiley   +1 more source