Results 201 to 210 of about 901,016 (342)

Plasma renin activity (PRA) and acute myocardial infarction (AMI) — more evidence for a positive association

open access: bronze, 1998
Jon D. Blumenfeld   +4 more
openalex   +1 more source

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2070-2079, July 2025.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo   +6 more
wiley   +1 more source

Exploratory Analysis of Practical Predictive Indices for the Efficacy of Mogamulizumab in Patients With Aggressive Adult T‐Cell Leukemia‐Lymphoma

open access: yesHematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT An exploratory analysis of past clinical trials was conducted to propose a predictive scoring system for the efficacy of mogamulizumab, an anti‐CC chemokine receptor 4 (CCR4) antibody, based on easily measurable parameters. Factors affecting progression‐free survival (PFS) were investigated using data from three clinical trials (NCT00920790 ...
Yutaka Shimazu   +3 more
wiley   +1 more source

<i>De Novo</i>-Designed APC/C Inhibitors Provide a Rationale for Targeting RING-Type E3 Ubiquitin Ligases. [PDF]

open access: yesJ Med Chem
Ruiz-Gómez G   +5 more
europepmc   +1 more source

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