Results 71 to 80 of about 3,904,888 (302)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An Analysis of Pragmatic Stance in Drug Negotiation Discourse Concerning National Medical Insurance Catalogue in China [PDF]
Athens Journal of Health and Medical SciencesAs a kind of public discourse, negotiation discourse is different from daily discourse, usually involving politics, economics, diplomacy, medical treatment, etc., and it is closely related to the national stance.
Hongmei Xi, Pengshuo Wang
doaj +1 more source
, 2015 The Eastern slopes of the Andes in North Peru are among the least developed parts of the country with the majority of people living in remote villages with little or no access to grid electricity.
Practical Action Peru
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2015 The Eastern slopes of the Andes in North Peru are among the least developed parts of the country with the majority of people living in remote villages with little or no access to grid electricity.
Practical Action Peru
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2015 The Eastern slopes of the Andes in North Peru are among the least developed parts of the country with the majority of people living in remote villages with little or no access to grid electricity.
Practical Action Peru
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Critical Discourse Analysis – Basic Assumptions, Implications, Application
Rocznik Andragogiczny, 2017 Numerous examples of research in the field of pedagogics which are using critical approach to discourse analysis show the diversity in theoretical background and methodology.
Violetta Kopińska
doaj +1 more source