Results 141 to 150 of about 8,430,940 (368)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
La libertad entre lo visible y lo invisible: límites y alcances de lo sublime katiano.
Revista de Estudios Sociales, 2009 The following essay is a view of the Kantian refection on the sublime in light of an interpretation that understands the Critique of Judgement as a project that is born from a concern for the relationship that appears within the sensible and ...
Ana María Amaya Villarreal .
doaj
The Marketing Philosophy and Challenges for the New Millennium [PDF]
The world has changed a lot during this millennium and it still keeps changing. For this reason it sounds logical, that together with these changes marketing faces a lot of challenges which need to be overcome.
Dainora GRUNDEY
core
What reasons do those with practical experience use in deciding on priorities for healthcare resources? A qualitative study [PDF]
, 2008 A. Hasman, Emma McIntosh, Tony Hope
openalex +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Fondazione dell'etica e materia del dovere in Edmund Husserl
Rivista Internazionale di Filosofia e Psicologia, 2011 Husserl's Foudation of Ethics and the Matter of Duty - This papers examines Edmund Husserl’s ethical thought in order to investigate the problem of the foundation of ethics in relation to the individuation of a possible matter fulfilling the empty form ...
Federica Buongiorno
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source