Results 41 to 50 of about 8,812,920 (310)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The Contribution of Individual Exercise Training Components to Clinical Outcomes in Randomised Controlled Trials of Cardiac Rehabilitation: A Systematic Review and Meta-regression

Sports Medicine - Open, 2017
Background While the clinical benefits of exercise-based cardiac rehabilitation are well established, there is extensive variation in the interventions used within these trials.
Bridget Abell, Paul Glasziou, Tammy Hoffmann   +2 more
doaj   +1 more source

‘We don't have recipes; we just have loads of ingredients’: explanations of evidence and clinical decision making by speech and language therapists [PDF]

, 2014
Rationale, aims and objectives: Research findings consistently suggest that speech and language therapists (SLTs) are failing to draw effectively on research-based evidence to guide clinical practice.
Beecham, Bernstein-Ratner, Brener, Conture, Dollaghan, Dowsell, Edwards, Ely, Entwistle, Federspil, Firenzuoli, Fourie, Gabbay, Gambrill, Gersten, Gillam, Greenhalgh, Hayhow, Heffernan, Higgs, Higgs, Higgs, Higgs, Iacono, Ioannidis, Jenicek, Joffe, Jones, Kahmi, Kahmi, Kida, King, Kitson, Klahr, Law, Law, Logemann, Lum, Lutterman, MacKenzie, Malin, McAllister, McCurtin, Metcalfe, Nail-Chiwetalu, Naylor, Newbold, O'Connor, Oliver, Papadopoulos, Profetto-McGrath, Rappolt, Richardson, Roulstone, Roulstone, Roulstone, Rousseau, Sackett, Sagan, Saldana, Schon, Shermer, Thompson, Tonelli, Walshe, Watts-Pappas, Zipoli   +66 more
core   +2 more sources

Exploration of the methodological quality and clinical usefulness of a cross-sectional sample of published guidance about exercise training and physical activity for the secondary prevention of coronary heart disease

BMC Cardiovascular Disorders, 2017
Background Clinicians are encouraged to use guidelines to assist in providing evidence-based secondary prevention to patients with coronary heart disease.
Bridget Abell, Paul Glasziou, Tammy Hoffmann   +2 more
doaj   +1 more source

A pragmatic approach for measuring data quality in primary care databases [PDF]

, 2014
There is currently no widely recognised methodology for undertaking data quality assessment in electronic health records used for research. In an attempt to address this, we have developed a protocol for measuring and monitoring data quality in primary ...
Beloff, Natalia, Boggon, Rachael, Dungey, Sheena, Puri, Shivani, Tate, A Rosemary, Williams, Tim   +5 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Effects of task-shifting from primary care physicians to nurses: an overview of systematic reviews

Human Resources for Health
Background Task-shifting from primary care physicians (PCPs) to nurses is a means of overcoming PCP shortages and meeting the needs of patients receiving primary care.
Muna Paier-Abuzahra, Nicole Posch, Klaus Jeitler, Thomas Semlitsch, Christina Radl-Karimi, Ulrike Spary-Kainz, Karl Horvath, Andrea Siebenhofer   +7 more
doaj   +1 more source

Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: an evidence map

Systematic Reviews, 2018
Background While in its early years the HIV epidemic affected primarily the male and the young, nowadays, the population living with HIV/AIDS is approximately 24% women, and its age composition has shifted towards older ages.
Gaelen P. Adam, Mengyang Di, Susan Cu-Uvin, Christopher Halladay, Bryant T. Smith, Suchitra Iyer, Thomas A. Trikalinos   +6 more
doaj   +1 more source

Journal Club Revisited: Teaching Evidence-Based Research and Practice to Graduate Students in a Professional Degree Program [PDF]

, 2019
A Journal Club can be a learning exercise that allows for the critique and pursuant analytic discussion of empirical studies, and encourages the public health, health administration, or health policy student to better understand how evidence-based ...
Caron, Rosemary M.
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source