Results 141 to 150 of about 301,813 (312)

Status of Clinical Practice Guideline Information Platforms

Xiehe Yixue Zazhi
Clinical practice guidelines represent the best recommendations for patient care. They are developed through systematically reviewing currently available clinical evidence and weighing the relative benefits and risks of various interventions.
ZHANG Xueqin, ZHAO Yun, LIU Jie, GE Long, XING Ying, REN Simeng, WANG Yifei, ZHANG Wenzheng, ZHANG Di, WANG Shihua, SUN Yao, WU Min, FENG Lin, WEN Tiancai   +13 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

, 2019
Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient
on behalf of the Pain in Children with Cancer Guideline Development Panel
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Clinical practice guidelines for gene therapy to treat hereditary hearing loss

Interdisciplinary Medicine
Hereditary deafness is a common neurosensory disorder, and 148 non‐syndromic deafness genes have been identified to date. Gene therapy has been used to treat a variety of genetic diseases, but no gene therapy drug for hereditary deafness has been ...
Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Hongyang Wang, Wenyan Li, Wenwen Liu, Xiaolong Fu, Zuhong He, Xiaoqiong Ding, Shan Sun, Qiaojun Fang, Yaodong Dong, Xuewei Zhu, Busheng Tong, Xianbao Cao, Min Guo, Xinmiao Fan, Qin Wang, Lu Ma, Tianhong Zhang, Yafeng Yu, Yongxin Li, Jiangang Fan, Yong Cui, Peina Wu, Hongzheng Zhang, Jie Tang, Weiwei Guo, Dingjun Zha, Fanglei Ye, Shuangba He, Wei Cao, Jianming Yang, Xiaoyun Qian, Yu Zhao, Jingwu Sun, Xiaowei Chen, Yu Sun, Ming Xia, Qiuju Wang, Huijun Yuan, Yong Feng, Weijia Kong, Shiming Yang, Haibo Wang, Maoli Duan, Xia Gao, Huawei Li, Lei Xu, Renjie Chai   +50 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Implementation of a Benzodiazepine Clinical Practice Guideline in an Outpatient Mental Health Setting

, 2019
In the treatment of mental health disorders, the use of benzodiazepines is increasingly falling out of favor due to rising evidence concerning the risk of abuse and dependence.
Jolley, Dana
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source