Quality assessment of clinical practice guidelines for sepsis and variations in recommendations. [PDF]
Li HY +4 more
europepmc +1 more source
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source
Evidence-based clinical practice guidelines for metabolic dysfunction-associated steatotic liver disease (MASLD) 2026. [PDF]
Akuta N +44 more
europepmc +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Translating the 2023 Malaysian Heart Failure Clinical Practice Guidelines (5th Edition) into primary care practice. [PDF]
Loo SY +5 more
europepmc +1 more source
T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ±
Sarah J. Wright +10 more
wiley +1 more source
Clinical practice guidelines for the prevention and management of postoperative nausea and vomiting (2025 edition). [PDF]
Hu J +6 more
europepmc +1 more source
Early onset scoliosis: Can Best Practice Guidelines Be Provided in Europe? [PDF]
Ilharreborde B +5 more
europepmc +1 more source
Clinical practice guidelines and quality standards for early intervention in psychosis: an AGREE II appraisal and systematic review of service components. [PDF]
Scognamiglio P +8 more
europepmc +1 more source

