Results 171 to 180 of about 251,052 (257)

Impact of Fiber Orientation in Electrospun PLA Scaffolds on Fluid Dynamics in a Custom Microfluidic Device

Advanced Healthcare Materials, EarlyView.
Fiber orientation in electrospun scaffolds affects permeability and fluid dynamics in microfluidic devices. Combining experimental data with computational fluid dynamic simulations, we show that aligned fibers enhance flow uniformity, reduce pressure and shear stress variability.
Elisa Capuana, Maria Testa, Chiara Di Marco, Francesco Lopresti, Vincenzo La Carrubba   +4 more
wiley   +1 more source

Vulnerability in research ethics: A systematic review of policy guidelines and documents. [PDF]

PLoS One
Grigis A, Beretta G, Borry P, Sanchini V.   +3 more
europepmc   +1 more source

1. Clinical Practice Guideline for the Diagnosis of Hepatocellular Carcinoma

Nihon Naika Gakkai Zasshi, 2014
Ryosuke Tateishi, Kazuhiko Koike
openaire   +4 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Large language models provide discordant information compared to ophthalmology guidelines. [PDF]

Sci Rep
Taloni A, Sangregorio AC, Alessio G, Romeo MA, Coco G, Busin LML, Sollazzo A, Scorcia V, Giannaccare G.   +8 more
europepmc   +1 more source

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

How to report and discuss subgroup analyses in clinical practice guidelines? Evaluation procedure of the clinical and statistical relevancy. [PDF]

Int J Clin Oncol
Ninomiya K, Miura S, Oya Y, Sakamoto T, Tanaka K, Teraoka S, Morise M, Morita S.   +7 more
europepmc   +1 more source

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Understanding different types of review articles: A primer for early career researchers.

Indian J Psychiatry
Ghosh A, Choudhury S.
europepmc   +1 more source

The management of patients who self-harm in adult inpatient mental health settings: A policy analysis of English NHS mental health trusts. [PDF]

PLoS One
Sharp H, Johnson J, Brennan C, Baker J.
europepmc   +1 more source