Results 81 to 90 of about 18,282,554 (308)
Frontiers in MedicineIntroductionKnee osteoarthritis (KOA) affects 528 million people globally, with prevalence projected to rise by 74.9% by 2050. Traditional treatments face limitations in long-term safety and efficacy, driving interest in complementary, alternative, and ...
Chuqing Luo +5 more
doaj +1 more source
The Korean Journal of Gastroenterology, 2019 The Korean clinical practice guidelines for the management of hepatocellular carcinoma (HCC) was originally enacted in 2004 by the Korean Liver Cancer Association (KLCA)-National Cancer Center (NCC) Korea in order to provide medical practitioners with ...
Ji Hoon Kim
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Practical Approach of Knowledge Management in Medical Science
CoRR, 2020 Knowledge organization, infrastructure, and knowledge-based activities are all subjects that help in the creation of business strategies for the new enterprise. In this paper, the first basics of knowledge-based systems are studied. Practical issues and challenges of Knowledge Management (KM) implementations are then illustrated.
Mahdi Bohlouli +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Scientific ReportsThis study aimed to explore the gap between attitudes towards and personally observed breaches of research integrity among medical postgraduates in China, a critical yet understudied population.
Tang Haitao +3 more
doaj +1 more source
Clinical application study of a novel fully automatic erythrocyte osmotic fragility analysis system
Biochemistry and Biophysics ReportsBackground: Existing erythrocyte osmotic fragility test (EFT) methods are constrained by subjectivity, poor reproducibility, and lack of standardization, limiting their clinical utility in thalassemia screening.
Zixin Deng +8 more
doaj +1 more source
Discontinuation of the PACE Plus trial: problems in patient recruitment in general practice
BMC Musculoskeletal Disorders, 2018 Background The PACE Plus trial was a multi-center, double-blinded, superiority randomized controlled trial (RCT) conducted in patients from Dutch general practice to investigate the efficacy of paracetamol and NSAIDs in acute non-specific low back pain ...
M. Schreijenberg +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source