Results 51 to 60 of about 451,692 (296)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Prescribing antibiotics when the stakes are higher — do GPs prescribe less when patients are pregnant? A retrospective observational study

BJGP Open, 2018
Background: Most oral antibiotics are prescribed by GPs, and they are therefore the most important influencers with regard to improving antibiotic prescription patterns.
Guro Haugen Fossum, Svein Gjelstad, Kari J Kværner, Morten Lindbaek   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Effects of Malpractice Pressure and Liability Reforms on Physicians’ Perceptions of Medical Care [PDF]

, 1997
Considerable evidence suggests that the medical malpractice liability system neither provides compensation to patients who suffer negligent medical injury nor seeks to penalize physicians whose negligence causes patient injury.
Kessler, Daniel P., McClellan, Mark B.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Overuse of Medical Tests: A New Health Risk Factor?

Acta Médica Portuguesa, 2016
Keywords: Medical Overuse; Practice Patterns, Physicians; Risk Factors; Risk Reduction Behavior.
Carlos Martins
doaj   +1 more source

Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the Theoretical Domains Framework [PDF]

, 2012
Background: The Theoretical Domains Framework (TDF) was developed to investigate determinants of specific clinical behaviors and inform the design of interventions to change professional behavior.
6 APUR, A Bishop, A de González Berrington, A Espeland, A Espeland, A Ferriman, A Francke, AE Bussières, AE Bussières, Andrea M Patey, André E Bussières, Anne E Sales, AP Farmer, B Carlsen, B Shaw, BM Fullen, BM Fullen, C Ammendolia, C Ammendolia, C Ammendolia, C Ammendolia, C Ammendolia, C Cherkin, CM Williams, D Di Iorio, D Morgan, D Shye, DH Solomon, DM Isaacs, E Ernst, EL Hurwitz, F Légaré, F Légaré, F Saillour-Glenisson, G Godin, G Kamberelis, G Kok, H Hsieh, H Schers, ID Graham, ID Graham, Intellipulse Pamr, J Cane, J Chenot, J Francis, J Francis, J Francis, J Francis, J Kitzinger, J McKenzie, J McKenzie, J Nyiendo, J Nyiendo, Jeremy M Grimshaw, Jill J Francis, JM Grimshaw, JM Grimshaw, K Iron, L Biggs, L Cochrane, LK Bartholomew, M Cabana, M Corbett, M Wensing, N Mays, N Scheurmier, National Board of Chiropractic Examininers, National Cancer Institute U.S. National Institutes of Health, OP Ryynanen, Open Clinical, P Aker, P Craig, P Little, P Sevigny, R Baker, R Bogdan, R Chou, R Chou, R Chou, R Chou, R Foy, R Grol, R Grol, R Phillips, S Michie, T Pincus, TJ Kaptchuk, TS Carey, TS Carey, TS Carey, V Etches, V-R Yvonne, W Assendelft, WR Hendee   +93 more
core   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Primary Care Health Workforce in the United States [PDF]

, 2011
Synthesizes findings about trends in the composition, supply, and distribution of the primary care workforce; demand for and pressures on primary care providers; and the impact of technologies, payment policies, market forces, and scope of practice ...
Catherine Dower, Edward O
core