Results 251 to 260 of about 14,060,785 (382)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis. [PDF]

Int J Stroke
Brakel BA, Rebchuk AD, Ospel J, Chen Y, Heran MK, Goyal M, Hill MD, Miao Z, Huo X, Sacco S, Yaghi S, Mai TD, Thomalla G, Boulouis G, Yamagami H, Hu W, Nagel S, Puetz V, Kristoffersen ES, Demeestere J, Qiu Z, Abdalkader M, Al Kasab S, Siegler JE, Strbian D, Fischer U, Coutinho J, Munckhof A, Aguiar de Sousa D, Campbell BC, Raymond J, Ji X, Saposnik G, Nguyen TN, Field TS.   +34 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Local excision for T1 rectal cancer: A population-based study of practice patterns and oncological outcomes. [PDF]

Colorectal Dis
Brennan KE, Farooq AO, Mckechnie TJ, Wiseman VH, Kong W, Bankhead CR, Heneghan CJ, Rai MS, Patel SV.   +8 more
europepmc   +1 more source

Data from the Dialysis Outcomes and Practice Patterns Study validate an association between high intravenous iron doses and mortality.

Kidney International, 2015
G. Bailie, M. Larkina, D. Goodkin, Yun Li, R. Pisoni, B. Bieber, N. Mason, Lin Tong, F. Locatelli, M. Marshall, M. Inaba, B. Robinson   +11 more
semanticscholar   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Perioperative Practice Patterns of Anaesthesiologists Surrounding Glucagon-Like Peptide-1 (GLP-1) Agonist Medications. [PDF]

Turk J Anaesthesiol Reanim
Brennan M, Han SH, Ockerman K, Mehta SD, Furnas HJ, Heath F, Mars P, Klenke A, Sorice-Virk SC.   +8 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Practice patterns and outcomes of conventional versus split-dose cisplatin in neoadjuvant ddMVAC in bladder cancer. [PDF]

Bladder Cancer
Callihan EB, Kuna EM, Eule CJ, Kessler ER, Flaig TW.   +4 more
europepmc   +1 more source