Results 71 to 80 of about 1,013,859 (238)
Advanced Science, EarlyView.We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao +23 more
wiley +1 more source
Unified Pragmatic Models for Generating and Following Instructions
, 2018 We show that explicit pragmatic inference aids in correctly generating and following natural language instructions for complex, sequential tasks.
Andreas, Jacob +2 more
core +1 more source
Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare
Advanced Science, EarlyView.Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu +10 more
wiley +1 more source
A Pragmatic Look at Schopenhauer’s Pessimism [PDF]
, 2019 Schopenhauer’s pessimistic philosophy is a depressing read. He writes many pages about how suffering is the norm, and any happiness we feel is merely a temporary alleviation of suffering. Even so, his account of suffering rings true
Parker, Allison
core
Advanced Science, EarlyView.This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu +9 more
wiley +1 more source
in defense of a presuppositional account of slurs [PDF]
, 2015 In the last fifteen years philosophers and linguists have turned their attention to slurs: derogatory expressions that target certain groups on the basis of race, gender, sexual orientation, nationality and so on.
Cepollaro, Bianca
core
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Self-criticism in a broken mirror [PDF]
, 1990 If we have no transparent access to our self, what kind of self-criticism is possible?
Kolb, David
core
Philosophy, 1959 Sometimes we draw conclusions about a thing's existence or its value by considering what are thought to be its consequences. I shall say that an argument is pragmatic when it consists in estimating an action, or any event, or a rule, or whatever it may be, in terms of its favourable or unfavourable consequences; what happens in such cases is that all ...
openaire +2 more sources
Advanced Science, EarlyView.Leveraging the multidimensional self‐catalytic merits of the alkali‐polyphenol synergistic self‐catalytic platform, this work delineates the intrinsic mechanism governing the regulation of hydrogel properties and puts forward an innovative design paradigm for frost‐tolerant electrode materials, providing critical scientific insights and technical ...
Mengting Zhou +10 more
wiley +1 more source