Results 91 to 100 of about 532,343 (308)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

open access: yesAdvanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao   +23 more
wiley   +1 more source

Success semantics: the sequel [PDF]

open access: yes, 2013
The aim of this paper is to reinterpret success semantics, a theory of mental content, according to which the content of a belief is fixed by the success conditions of some actions based on this belief.
Nanay, Bence
core  

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

open access: yesAdvanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu   +10 more
wiley   +1 more source

Pragmatic Failures in Intercultural Communication: Evidence from Jordan

open access: yesПсихолінгвістика
Aim. This paper investigates the pragmatic errors of Jordanian EFL learners from a cultural perspective on communication. It is suggested that pragmatics, or the study of how language is used in context, plays a crucial role in L2 learners’ communicative
Абдель Рахман Алтахіне   +2 more
doaj   +1 more source

Face-Threatening Aspect of Refusal Speech Acts: A Contrastive Study [PDF]

open access: yesJournal of Modern Research in English Language Studies, 2015
Professionalism in communication is a matter of concern for speakers of all languages. Awareness about some features such as face-threatening property of refusal speech acts leads language users to apply some specific linguistic forms.
Nargol Mokhtari
doaj  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

Scalable, Low‐Cost, Freeze‐Resistant Hydrogels by Alkali‐Polyphenol‐Triggered Polymerization for Low‐Temperature Self‐Powered Triboelectric Sensor

open access: yesAdvanced Science, EarlyView.
Leveraging the multidimensional self‐catalytic merits of the alkali‐polyphenol synergistic self‐catalytic platform, this work delineates the intrinsic mechanism governing the regulation of hydrogel properties and puts forward an innovative design paradigm for frost‐tolerant electrode materials, providing critical scientific insights and technical ...
Mengting Zhou   +10 more
wiley   +1 more source

PRAGMATIC FAILURE IN LISTENING CLASS A CASE STUDY OF X GRADE STUDENTS OF SMK TAMANSISWA CILACAP

open access: yesJurnal Penelitian Humaniora, 2015
In communication, sometimes people hear the unrelated utterances between speaker and hearer but the conversation is usually still continued that way. In this way, the pragmatic role is needed.
Septiyana Pengesti
doaj  

Reason and Experience in Buddhist Epistemology [PDF]

open access: yes, 2013
Among the key factors that play a crucial role in the acquisition of knowledge, Buddhist philosophers list (i) the testimony of sense experience, (ii) introspective awareness (iii) inferences drawn from these directs modes of acquaintance, and (iv) some ...
Coseru, Christian
core   +2 more sources

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