Results 91 to 100 of about 2,198 (193)
Recent Advances in Diagnostics and Therapeutics for Paediatric Thyroid Cancer
Journal of Paediatrics and Child Health, Volume 61, Issue 5, Page 666-675, May 2025.ABSTRACT Purpose of Review Paediatric thyroid cancer management traditionally relied on extrapolation from adult data and, despite good survival outcomes, often involved extensive surgical approaches and radioactive iodine (RAI) therapy with potentially life‐long complications.
Joel A. Vanderniet +9 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 8, April 2025.ABSTRACT Background Hundreds of cancer drugs are approved globally based on surrogate endpoint response rate (RR). However, the characteristics of RR‐based approvals remain unknown. Methods In this retrospective study, all cancer drug‐indication pairs approved based on RR in the United States and China up to December 2023 were analyzed. Results A total
Ting Zhu, Jinjia Zhong, Yafang Huang
wiley +1 more source
RET kinase inhibitors for -altered thyroid cancers
Therapeutic Advances in Medical Oncology, 2022 Precision oncology has opened a new era in cancer treatment focused on targeting specific cellular pathways directly involved in tumorigenesis. The REarrangement during Transfection ( RET ) proto-oncogene is involved in the pathogenesis of various ...
Danica M. Vodopivec, Mimi I. Hu
doaj +1 more source
Cancer Science, Volume 116, Issue 4, Page 1094-1106, April 2025.Identifying actionable mutations and gene fusions of KRAS wild‐type pancreatic ductal adenocarcinoma offers significant potential for targeted and immune‐based therapies, by retrospective study and genomic profiling analysis, together with comparative analysis of TCGA‐PAAD data.
Dan Su +11 more
wiley +1 more source
RET fusion-positive non-small cell lung cancer complicated with disseminated hematogenous tuberculosis during first-line Pralsetinib treatment: A case report [PDF]
, 2023 Yu Chen +5 more
openalex +1 more source
The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair
International Wound Journal, Volume 22, Issue 4, April 2025.ABSTRACT Tyrosine kinase inhibitors (TKIs) can treat various cancers, primarily through their antiangiogenic effects. However, as angiogenesis is crucial for successful wound healing, TKIs may adversely impact wound repair. This review analysed all 63 FDA‐approved TKIs and identified evidence for wound healing and repair implications in 24 agents.
William J. Nahm, Vincent Falanga
wiley +1 more source
Identificazione di mutazioni driver nel tumore del polmone non a piccole cellule mediante biopsia liquida: fusione di RET e terapia con pralsetinib [PDF]
, 2021 Marco Russano
openalex +1 more source
Recent Progress in the Systemic Treatment of Advanced/Metastatic Cholangiocarcinoma [PDF]
, 2020 Cholangiocarcinomas (CCAs) comprise of a heterogeneous group of cancers arising in the biliary tract (intrahepatic or iCCA, perihilar or pCCA and distal or dCCA; the latter are known under the collective term of eCCA), each subtype having its own ...
Arkenau, HT +3 more
core
Molecular Oncology, Volume 19, Issue 3, Page 614-634, March 2025.Colorectal cancer (CRC) metastases in liver and brain exhibited organ‐specific frequencies of consensus molecular subtypes (CMS). In terms of overall survival, CMS4 was the most beneficial subtype for patients with CRC metastases in the liver. Brain metastases were enriched for the metabolic subtype (CMS3) and certain metabolic markers that correlated ...
Barnabas Irmer +20 more
wiley +1 more source