Hepatitis C Prevalence on the Rise but Screening at Safety Net Institutions Lagging behind. [PDF]
Int J Hepatol, 2023 Introduction. In the United States, the hepatitis C virus (HCV) is a leading contributor to liver‐related illnesses and fatalities. Despite effective antiviral medications, acute infections have increased in recent years, likely due to IV drug use and the opioid epidemic.
Prasa J +3 more
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Multivariate estimation of substructure amplitudes for a single-wavelength anomalous diffraction experiment. [PDF]
Acta Crystallogr D Struct Biol, 2023 A new equation for the calculation of substructure‐factor amplitudes for substructure detection from a single‐wavelength anomalous diffraction experiment produces better results compared with the currently used estimates in test cases.To determine a substructure from single‐wavelength anomalous diffraction (SAD) data using Patterson or direct methods ...
Pannu NS, Skubák P.
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Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure. [PDF]
Acta Crystallogr D Struct Biol, 2022 Multiple approaches to data merging and scaling and anomalous substructure determination were used to solve the structure of a large asymmetric unit from weakly diffracting crystals by sulfur SAD.The application of sulfur single‐wavelength anomalous dispersion (S‐SAD) to determine the crystal structures of macromolecules can be challenging if the ...
Mou TC, Zeng B, Doukov TI, Sprang SR.
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Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4. [PDF]
Acta Crystallogr F Struct Biol Commun, 2021 Solution of the structure of the DNA‐binding domain of interferon regulatory factor 4 bound to its interferon‐stimulated response element by native intrinsic phosphorus and sulfur single‐wavelength anomalous dispersion methods (native SAD) is described.Pivotal to the regulation of key cellular processes such as the transcription, replication and repair
Agnarelli A +4 more
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Implementation of a crossed-slit system for fast alignment of sealed polycapillary X-ray optics. [PDF]
J Synchrotron Radiat, 2020 A fast X‐ray focusing polycapillary alignment method was implemented and tested using a compact short‐pulse laser‐driven broadband X‐ray source.A new modification of a table‐top laser‐driven water‐jet plasma X‐ray source has been successfully implemented and commissioned at the Extreme Light Infrastructure (ELI) Beamlines user facility.
Zymaková A +7 more
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Pregabalin poisoning: Evaluation of dose-toxicity relationship. [PDF]
Br J Clin Pharmacol, 2022 Context Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur. Aim To determine the dose‐toxicity relationship of pregabalin. Methods Dose‐toxicity data of isolated pregabalin poisonings were collected from (1) a prospective study performed by the Dutch Poisons Information Centre (4 April 2014 to 4 October 2016) and ...
Rietjens SJ +4 more
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Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults - A Case Report and Systematic Review. [PDF]
Rev Med VirolABSTRACT This case report and systematic review describe the complete clinical course of chronic gastric ulceration complicating acute gastrointestinal CMV disease in a 72‐year‐old immunocompetent woman, with demonstrable response to ganciclovir but not valganciclovir.
Al-Timimi Z, Geddes A, Lawrence R.
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Perceptional and socio-demographic factors associated with household drinking water management strategies in rural Puerto Rico. [PDF]
PLoS ONE, 2014 Identifying which factors influence household water management can help policy makers target interventions to improve drinking water quality for communities that may not receive adequate water quality at the tap.
Meha Jain +3 more
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Deep-learning map segmentation for protein X-ray crystallographic structure determination. [PDF]
Acta Crystallogr D Struct BiolElectron‐density map segmentation into protein and solvent regions using deep neural networks improves density modification in X‐ray structure solution from experimental phases.When solving a structure of a protein from single‐wavelength anomalous diffraction X‐ray data, the initial phases obtained by phasing from an anomalously scattering substructure
Skubák P.
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Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions [PDF]
J Appl CrystallogrA tomography‐based ray‐tracing approach for analytical absorption corrections for X‐ray crystallography is presented. Several examples from long‐wavelength macromolecular crystallography experiments demonstrate the efficacy of this new method.Processing of single‐crystal X‐ray diffraction data from area detectors can be separated into two steps. First,
Lu Y +11 more
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