Results 221 to 230 of about 29,034 (242)
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Praziquantel in the Treatment of Cysticercosis
JAMA: The Journal of the American Medical Association, 1986To the Editor.— The recent article on cysticercosis in Los Angeles County documents 497 patients followed up over an 11-year period and underscores the need for heightened physician awareness of this seemingly rare disease. 1 While the authors note that anticonvulsant therapy may be used to control neurocysticercosis and mention the role of surgical ...
Jay A. Levin, J. Graham Smith
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European Journal of Clinical Pharmacology, 2019
The study sought to determine the effect of ketoconazole (KTZ) on the pharmacokinetics of praziquantel (PZQ) and on the formation of its major hydroxylated metabolites, cis- and trans-4-OH-PZQ, and X-OH-PZQ in healthy subjects.Two treatments were evaluated by single-dose PK studies; the reference treatment was a 20 mg/kg dose of praziquantel given ...
Lovejoy Nleya +6 more
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The study sought to determine the effect of ketoconazole (KTZ) on the pharmacokinetics of praziquantel (PZQ) and on the formation of its major hydroxylated metabolites, cis- and trans-4-OH-PZQ, and X-OH-PZQ in healthy subjects.Two treatments were evaluated by single-dose PK studies; the reference treatment was a 20 mg/kg dose of praziquantel given ...
Lovejoy Nleya +6 more
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Schistosomiasis control: praziquantel forever?
Molecular and Biochemical Parasitology, 2014Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate hosts are not easy to attack, chemotherapy is the main approach for schistosomiasis control. Praziquantel is currently the only available antischistosomal drug and it is distributed mainly through mass administration programs to millions of people every year.
Cioli D +3 more
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Schistosome resistance to praziquantel
Drug Resistance Updates, 1998Praziquantel (PZQ) is the drug of choice for the treatment of human schistosomiasis. In 1994, it was first demonstrated that by sustained drug pressure on a Schistosoma mansoni strain in laboratory conditions resistance to PZQ can develop. Studies in Senegal and Egypt, both schistosomiasis endemic areas, have found that there are schistosome strain(s ...
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Determination of praziquantel and of praziquantel in tablets by gas–liquid chromatography
The Analyst, 1992Praziquantel was determined by gas–liquid chromatography (GLC). The determination was based on the concept of internal standardization; papaverine was used as the internal standard. Five independent analyses of two samples containing 0.105 and 1.370 mg cm–3 of praziquantel showed relative standard deviations of 0.540 and 0.155% respectively.
J. Schnekenburger, H. Saleh
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The anthelmintic action of praziquantel
Parasitology Today, 1988Although fairly expensive (around US$4.00 per single dose) praziquantel is now the most favoured drug against all forms of schistosomiasis, and against many other helminth infections. It is now marketed by four companies: E. Merck and Bayer (F.R.G.), Ames-Myers (USA), and Shin-Poon Pharmaceuticals (S. Korea).
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ChemInform Abstract: Structure of a Praziquantel Analogue
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. Rubio +3 more
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Schistosomiasis and Praziquantel
Annals of Internal Medicine, 1983Z, Farid, C K, Wallace
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