Results 51 to 60 of about 1,475 (111)

Identifying Pediatric Drug Safety Knowledge Gaps: An Integrated Approach Leveraging Real‐World Data, a Biomedical Knowledge Base, and Postmarketing Surveillance Data

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 667-676, October 2025.
ABSTRACT Background Drug safety has historically been understudied in pediatric populations, rendering them “therapeutic orphans.” Pediatric drug indications and dosages are often inferred by extrapolating safety, efficacy, and dosing data from adult studies, leading to widespread off‐label use.
Saurabh Rahurkar, Jiayi Ouyang, Pallavi Jonnalagadda, Xiaofu Liu, Shijun Zhang, Chien‐Wei Chiang, Lei Wang, Aditi Shendre, Lang Li   +8 more
wiley   +1 more source

Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review

Acta Paediatrica, Volume 114, Issue 10, Page 2480-2489, October 2025.
A substantial proportion of oral drug administrations in children require manipulation due to the lack of age‐appropriate formulations. Common methods such as splitting, crushing, and dispersing tablets in fluids can compromise dose accuracy because of e.g., drug solubility.
M. Paulsson, R. Hamre Svendsen, J. K. N. Andersen, S. Kälvemark Sporrong, Y. Andersson, I. Tho   +5 more
wiley   +1 more source

Modeling of micro- and nanodroplets

Moldavian Journal of the Physical Sciences, 2020
In this review, a formula that determines the curvature-dependent surface tension in a droplet with two phases has been discussed. Taking into account the dependence of the surface tension on the system size, nonlinear differential equations describing ...
Baranov S.
doaj   +1 more source

Avaliaçao do risco de morte súbita na síndrome de pré-excitaçao ventricular manifesta pela estimulaçao atrial transesofágica

Journal of Cardiac Arrhythmias, 1993
Cinqüenta e dois pacientes com idade média de 33,5 anos, sendo 29 do sexo feminino, foram submetidos à estimulaçao atrial transesofágica (EA 1), com o objetivo de avaliar o risco de morte súbita na síndrome de pré-excitaçao ventricular.
Eduardo Machado ANDRÉA, Martha Rustum ANDRÉA, Washington Andrade MACIEL   +2 more
doaj   +4 more sources

Analysis of behaviour of contact between the profiled steel sheeting and the concrete

Journal of Civil Engineering and Management, 2006
In designing composite structures it is necessary to verify the following three sections: normal, diagonal and horizontal. The behaviour of composite steel‐concrete structures with external profiled reinforcement is directly dependent on the ...
Juozas Valivonis
doaj   +1 more source

Lobação do fígado e distribuição intraparenquimal da veia porta no preá (Galea spixii Wagler, 1831).

Biotemas, 2011
A lobação e a distribuição intraparenquimal da veia porta foi descrita com base em estudos realizados em 10 exemplares de preás. A veia porta foi canulada e perfundida com solução de acetato de vinil e o fígado imerso em solução ácido sulfúrico para ...
Gleidson Benevides Oliveira, Márcio Nogueira Rodrigues, Roberto Sávio Bessa Silva, José Fernando Gomes Albuquerque, André Menezes Vale, Carlos Eduardo Bezerra Moura, Moacir Franco Oliveria   +6 more
doaj   +1 more source

PAVEL PULBERE – PROFESOR, MANAGER PRIN VOCAȚIE ȘI EXEMPLU DE BONOMIE

Acta et Commentationes: Ştiinţe Exacte şi ale Naturii, 2019
Printre cele mai luminoase și vii chipuri care îmi apar deseori este cel al dlui profesor, doctor în științe biologice, conferențiar universitar, Pavel Pulbere, pe care l-am cunoscut de când eram elevă, participantă la Olimpiadele republicate de ...
Lora MOȘANU-ȘUPAC
doaj   +1 more source

Taxorchis caviae sp. n. (Trematoda, Paramphistomidae), parasito intestinal de Cavia aperea Erxleben, 1777 (Rodentia, Caviidae)

Memorias do Instituto Oswaldo Cruz, 1981
Descreve-se uma nova espécie de trematóide paranfistomídeo, encontrado no intestino grosso de preá, Cavia aperea aperea Erxleben, 1777, roedor silvestre muito freqüente no Estado de São Paulo de outras regiões do país.
Urara Kawazoe, Nelson da Silva Cordeiro, Paulo de Toledo Artigas   +2 more
doaj   +1 more source

PENGEMBANGAN INSTRUMEN PENILAIAN KINERJA UNTUK MENGUKUR KOMPETENSI SISWA DALAM KEGIATAN PRAKTIKUM KIMIA DI SMA/K

Jurnal Inovasi Pendidikan Kimia, 2018
Penelitian ini bertujuan untuk mengembangkan instrumen penilaian kinerja untuk mengukur kompetensi siswa dalam kegiatan praktikum kimia di SMA/K. Metode yang digunakan adalah Research and Development (R D), yang terdiri atas tahap pengembangan, validasi,
Pintaka Kusumaningtyas, Runita Eka Yusvitasari, Abdul Majid   +2 more
doaj   +1 more source

A microestrutura e o desenvolvimento dos órgãos genitais masculinos de preás (Galea spixii) criados em cativeiro The microstructure and development of male genital organs of Spix's yellow-toothed cavy (Galea spixii) bred in captivity

Pesquisa Veterinária Brasileira, 2012
O preá do semiárido nordestino (Galea spixii) é um roedor pertencente à família Caviidae. São encontrados nas regiões da Caatinga e do Cerrado Brasileiro e se reproduz ao longo do ano, apresentando um período de gestação de 48 dias e uma ninhada de 2 a 4
Paulo R.S. Santos, Moacir F. Oliveira, Alexandre R. Silva, Carolina Maria O.N. Camargo, Antônio C. Assis Neto   +4 more
doaj