Results 31 to 40 of about 211 (93)

Pharmacokinetic Model Based Sensitivity Analysis to Lower Recruitment Burden for Young Children Requiring Intravenous Immunoglobulin G Replacement

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.
ABSTRACT To support a post‐marketing requirement for pharmacokinetic (PK)‐focused assessments in patients ages 2–16 years, a model‐informed drug development approach was used to overcome enrollment barriers in recruiting pediatric subjects with primary immune deficiency (PID) disorders under Age 6 in a Phase 4 pediatric study.
Todd Dumas, Shahram Mehr, Rebecca Avila, Amy Doman, Kaitlin Kestenberg, Isaac Melamed   +5 more
wiley   +1 more source

The Current Use and Future Perspectives of Biosimilars in Pediatric Healthcare: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims The integration of biosimilars into pediatric healthcare represents a significant evolution in treatment accessibility and cost‐effectiveness. Biosimilars—biological products highly similar to already approved biologics, have emerged as promising alternatives for managing chronic and rare pediatric conditions, including ...
Zubaier Ahmed, Tasfiah Tasnim Maha, Sanjana Nowsher, Wasima Taslim, Fatema‐Tuz‐Zohora, Sabrina Sharmin, Hasina Yasmin   +6 more
wiley   +1 more source

Analysis of Mandatory Post‐Marketing Surveillance Studies Supports Revised Regulatory Requirements in Korea

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Purpose The objective of this analysis was to determine the contribution to the understanding of product benefit/risk made by non‐randomized, observational post‐marketing surveillance (PMS) studies previously required by the Ministry of Food and Drug Safety (MFDS) re‐examination system and conducted by Pfizer in Korea over 2000–2024. Methods A
Kevin Wolter, Seung‐Hee Jeong, Ju‐Won Woo, Eunsol Kim, Yoosun Lee, Sera Cha, Evelyn Moy, Rod Junor   +7 more
wiley   +1 more source

Informing Dose for Pediatric Rare Diseases—A Survey of Recent Orphan Drugs Approvals

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Collectively, pediatric rare diseases affect millions of children worldwide. Yet, treatment options are limited. Dose selection presents unique challenges in pediatric rare disease drug development. Traditional dose‐finding approaches are impractical for these populations, and conventional pediatric dosing methods like exposure matching face ...
Elimika Pfuma Fletcher, Chloe Kim, Hannah Mei, Bilal AbuAsal, Sherbet Samuels, Rajanikanth Madabushi, Anuradha Ramamoorthy   +6 more
wiley   +1 more source

How to Diagnose Prisons' Failures: Three Perspectives on Officers' Responsibilities

Journal of Applied Philosophy, Volume 43, Issue 1, Page 16-33, February 2026.
ABSTRACT Prison officers play a vital role in shaping prison conditions. Assessing their responsibility for, and potential role in reforming, the prison's failures is an urgent and important task in corrective justice efforts. This article takes up this task, with a focus on the US prison context, by applying and critically examining two general ...
Candice Delmas
wiley   +1 more source

The Relationship between Personal Growth Initiative and Personal Self‐Concept: The Double‐Edged Mediating Effect of Meaning in Life

Journal of Counseling &Development, Volume 104, Issue 1, Page 65-77, January 2026.
ABSTRACT This study examined the relationship between personal growth initiative and personal self‐concept, investigating the mediating roles of the presence of meaning and search for meaning within a parallel mediation model, using a sample of 211 Romanian adults.
Isabela‐Bianca Dumitru, Adrian Opre
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Galling by Trichilogaster sp. suppresses the growth of Acacia auriculiformis saplings

Biological Control
Pre-release efficacy assessments (PREAs) are used in weed biological control to predict the potential impact of prospective agents. These assessments enable the most damaging agents to be prioritised for host testing and release.
Christine H. Sanderson, Ryan Zonneveld, Matthew F. Purcell, S Raghu   +3 more
doaj   +1 more source

A Massive Grant‐Free Random Access Scheme Based on Spectrum Sensing and Preamble Delay

IET Communications, Volume 20, Issue 1, January/December 2026.
This paper introduces cognitive radio (CR) and preamble delay (PD) to reduce access collisions, together with non‐orthogonal multiple access (NOMA) to improve spectrum efficiency, and thus proposes an efficient CR‐NOMA‐PD‐based massive grant‐free random multiple access scheme.
Jing Zhang, Zhuang‐Zhuang Wei, Yu‐Qi Zhang, Hong‐Xu Gao, Hai‐Tao Zhao, Hong‐Bo Zhu   +5 more
wiley   +1 more source

Evaluation of the Yes to Veg! Programme, a Food Systems Approach to Increase Vegetable Exposure and Agency in Pre‐School Age Children: A Quasi‐Experimental Study

Maternal &Child Nutrition, Volume 22, Issue 1, January 2026.
ABSTRACT Children's early years food environment can influence dietary habits. We evaluated Yes to Veg! a 4‐week nursery‐based programme on pre‐school children's vegetable exposure, consumption and agency. A quasi‐experimental study in 11 nurseries (6 intervention/5 controls) located in socio‐economically deprived areas of Glasgow, Scotland. Yes to Veg!
Ada Lizbeth Garcia, Zabrina Zerr, Irina Martin, Alison Parrett   +3 more
wiley   +1 more source