Results 101 to 110 of about 10,887,074 (251)

The Lions Sports Academy TackleTEK Tool: The intra-and inter-coach reliability of assessing tackling competency in rugby union.

PLoS ONE
Tackling skill tests in rugby aim to evaluate skill competency, but their reliability to detect meaningful changes in tackling competency over time remains uncertain.
Robert Owen, Camilla J Knight, Will Page, Jamie Tallent, Liam Kilduff, Mark Waldron   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Validation of the Emoji Faces Scale for Dental Pain Assessment in Adults: An Observational Pre–Post Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Accurate pain assessment is essential for effective dental care. Traditional tools like the Numeric Rating Scale (NRS) and Color Analog Scale (CAS) may be limited in patients with language, literacy, or cognitive barriers.
R Priyanka, P Roland Prethipa, M Surenthar   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Relationships and agreement between Yo-Yo intermittent recovery test level 1 performance and laboratory VO2max in adolescent male soccer players: roles of maturity status, playing position, and running economy

Annals of Human Biology
Background Accurate assessment of aerobic fitness is essential in youth soccer. The Yo-Yo Intermittent Recovery Test Level 1 (YYIR1) provides a practical estimate of maximal oxygen uptake (VO2max), but its agreement with laboratory values across maturity
Yaohui Xu, Naidan Xu, Rou Wang, Weiming Li, Indy Man Kit Ho, Eric Tsz-Chun Poon, Weijun Liu, Haochong Liu   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Automated Assessment of Ki-67 Labeling Index Using Cell-Level Detection and Classification in Whole-Slide Images

Diagnostics
Background: The Ki-67 labeling index (LI) is a widely used marker of tumour proliferation, yet its manual assessment is time-consuming and subject to substantial inter-observer variability.
Masayuki Tsuneki, Meng Li, Fahdi Kanavati   +2 more
doaj   +1 more source

Multilateral Agreement On Investments (MAI) - A Critical Assessment From an Industrial Economics Point of View [PDF]

Though the Multilateral Agreement on Investment (MAI) has failed, the original draft is likely to serve as a basis for future negotiations. This article gives a critical assessment of the draft from an industrial economics point of view.
Andreas Polk
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Agreement between GAITRite and conventional gait assessment tools which can be utilized in community settings – A cross-sectional pilot study

Clinical Epidemiology and Global Health
Background/objectives: GAITRite is often considered as the gold standard for gait assessment in the clinical settings. However, the utility of GAITRite is limited in the community settings where technology is not feasible.
Tittu Thomas James, V. SelvaGanapathy, Pradnya Dhargave, Dhwani Parekh   +3 more
doaj   +1 more source