Results 41 to 50 of about 3,157,747 (296)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Experimental Investigation on Knock Characteristics from Pre-Chamber Gas Engine Fueled by Hydrogen

Energies
Hydrogen-fueled engines require large values of the excess air ratio in order to achieve high thermal efficiency. A low value of this coefficient promotes knocking combustion.
Ireneusz Pielecha, Filip Szwajca, Kinga Skobiej   +2 more
doaj   +1 more source

Combustion analysis in a natural gas engine with pre-chamber by three-dimensional numerical simulation

Nihon Kikai Gakkai ronbunshu, 2015
Highly efficient natural gas engines have been widely used in wide range of sectors from industry and transportation. However, because combustion process in gas engines with a pre-chamber is very complicated, it is difficult to experimentally investigate
Satoshi HOKIMOTO, Tatsuya KUBOYAMA, Yasuo MORIYOSHI, Toshio YAMADA   +3 more
doaj   +1 more source

Peripheral Anterior Chamber Depth and Angle Measurements Using Pentacam After Implantation of Toric and Non-toric Implantable Collamer Lenses

Frontiers in Medicine, 2021
Purpose: To evaluate the characteristics of peripheral anterior chamber measurements by Pentacam after posterior implantable collamer lenses (ICL) and toric ICL (TICL) with central hole (V4c) implantation.Methods: Prospective, non-randomized consecutive ...
Jiao Zhao, Jing Zhao, Jing Zhao, Jing Zhao, Wen Yang, Huamao Miao, Huamao Miao, Huamao Miao, Lingling Niu, Lingling Niu, Lingling Niu, Jianmin Shang, Jianmin Shang, Jianmin Shang, Xiaoying Wang, Xiaoying Wang, Xiaoying Wang, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou   +19 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Students’ Satisfaction with Hybrid Learningin the School of Accountancy, Universityof the Thai Chamber of Commerce:A Case Study of Principles of Accounting

, 2011
The primary objective of this research was to study student’s satisfactory levels withhybrid learning, School of Accountancy, University of the Thai Chamber of Commerce:A Case Study of Principles of Accounting.
Chowivattana, Isaree
core   +1 more source

Experimental Study of Ignition Characteristics in Oblique-Injected Annular Combustors Using a Pre-Chamber Ignition System

Aerospace Research Communications
In this work, a pre-chamber ignition system is used to initiate the ignition in a premixed oblique-injected annular combustor. Although the introduction of the oblique-injecting burner in the gas turbine improved the gyratory flow motion and flow ...
Haroun Hassan, Haroun Hassan, Chenghao Qian, Hui Wang, Jinxiang Zhu, Haiwen Ge, Elsayed Barakat, Elsayed Barakat, Elsayed Barakat, Gaofeng Wang   +9 more
doaj   +1 more source

Research on the Pressure Impact Characteristic of Continuous Rotary Electro-Hydraulic Servo Motor

IEEE Access, 2019
In order to reduce the pressure impact of continuous rotary electro-hydraulic servo motor, ensure the smooth pressure transition during the motor commutation, and improve the control accuracy, a kind of pre-compression chamber structure was proposed. The
Xiaojing Wang, Zhiqi Shen, Shuai Chen, Yuwei Sun   +3 more
doaj   +1 more source