Results 151 to 160 of about 3,757,704 (310)

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥ 20 weeks to a tertiary fetal medicine unit (2020–2025).
Hadas Miremberg, May Shabat, Maya Stok, Vered Offer Glasner, Adi Botvinik, Mordechai Shohat, Michal Levy, Yuval Yaron, Roee Birnbaum, Sharon Perlman, Gustavo Malinger, Karina Krajden Haratz   +11 more
wiley   +1 more source

Cardiovascular Complications in Pre-eclampsia: Can they be Predicted Electrocardiographically?

European Medical Journal, 2019
Background: Pre-eclampsia is a common condition that causes significant morbidity and mortality in pregnant women; the occurrence of cardiovascular complications aggravates the disease. Efforts have been made to predict the complications of pre-eclampsia,
Robert Adrianto Raharjo, Yan Herry, Udin Bahrudin, M. Besari Adi Pramono, Destrian Ekoputro Wismiyarso   +4 more
doaj  

Non‐Invasive Prenatal Diagnosis of Haemoglobinopathies: From Concept to Clinical Reality

Prenatal Diagnosis, EarlyView.
ABSTRACT Haemoglobinopathies are the most prevalent monogenic disorders worldwide, contributing significantly to childhood morbidity and mortality. Preventive strategies, including carrier screening and prenatal diagnosis, have successfully reduced disease incidence in regions with established programmes.
Irene Leonidou, Leila Sallie, Morgan Jean Bell‐Ricketts, Alexandros Abdel Massih, Lisa Joy Kaiser, Ashley Hoi Kiu Wong, María Teresa Martín Monreal, Panicos Shangaris   +7 more
wiley   +1 more source

Genome‐Wide NIPT With Fetal‐Fraction Enrichment and BinDel: Clinical Cohort Evaluation of Microdeletion and ‐Duplication Detection

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the analytical and clinical performance of fetal fraction (FF) enriched genome‐wide noninvasive prenatal testing (GW‐NIPT) for the detection of clinically relevant copy number variants (CNVs) down to 1 Mb. Methods We retrospectively analyzed 10,501 singleton pregnancies tested with FF enrichment‐based GW‐NIPT between ...
Karmen Vaiküll, Priit Paluoja, Signe Mölder, Vadym Gryshchenko, Neeme Tõnisson, Andres Salumets, Kaarel Krjutškov   +6 more
wiley   +1 more source

Trophoblast and Pre-Eclampsia

, 2015
Pre-eclampsia is a dangerous complication of the second half of pregnancy, labour or the early puerperium. Placental pre-eclampsia is caused by pathological alterations of the process of placentation in early pregnancy. Maternal pre-eclampsia is provoked
ROSSI, Alberto
core   +1 more source

Factors Associated With the Absence of Fetal Autopsy: Perception of Healthcare Professionals From a French Cross‐Sectional Survey

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Despite recent recommendations highlighting the importance of fetal autopsy for genetic counseling and recurrence prevention, its uptake has declined. This study aimed to identify factors associated with absence of fetal autopsy from the perception of healthcare professionals (HP). Methods National cross‐sectional online survey among
Camille Reyl, Sophie Martin‐Berenguer, Fanny Sauveste, Mélie Sarreau   +3 more
wiley   +1 more source

Pregnancy in CTD‐interstitial lung disease: Current evidence, clinical challenges, and a proposed management algorithm

Rheumatology &Autoimmunity, EarlyView.
Summary of pregnancy management in CTD‐ILD across preconception, antenatal, and postpartum phases, emphasizing risk stratification and multidisciplinary care. 6MWT, 6‐min walk test; CTD‐ILD: connective tissue disease‐interstitial lung disease; DLCO, diffusion capacity of the lung for carbon monoxide; FVC, forced vital capacity; MDT, multidisciplinary ...
Khaled Aldhuaina, Ghaydaa Aldabie, Mohammad Abdulsalam, Ali Jawad   +3 more
wiley   +1 more source

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether the associations between pre‐pregnancy risk factors and severe preeclampsia/eclampsia (SPE) and/or HELLP syndrome differ between singleton and twin pregnancies. Design A population‐based retrospective cohort study. Setting British Columbia (BC), Canada.
Mackenzie Campbell, Johanna Koegl, Jeffrey N. Bone, Sofia Nicolls, Janet Lyons, Chantal Mayer, Kenneth I Lim, Julie Van Schalkwyk, K. S. Joseph, Sarka Lisonkova, the ORQA group, A. Christoffersen‐Deb, S. Derikvand, S. John, L. Richter, M. Rougerie, Y. Sabr, M. Vidler   +17 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source