Results 201 to 210 of about 293,944 (256)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

EasyBOPT: A Digitally Standardized Protocol to Simplify and Reproduce the Biologically Oriented Preparation Technique (BOPT)-Technique Description and Case Series. [PDF]

J Clin Med
Agustín-Panadero R, Loi I, Roig-Vanaclocha A, Amengual-Lorenzo J, Chust-López C, García-Selva M, Gómez-Polo M, Serra-Pastor B.   +7 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Correction for Liao et al., Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Cetrorelix suppresses the dominant follicle and synchronizes follicular waves and ovulation in cattle†. [PDF]

Biol Reprod
Farmer DR, Leonardi CEP, Adams GP, Campbell J, Oliveira JLO, Singh J.   +5 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Huddling and food availability shape seasonal torpor and energetics of juvenile garden dormice. [PDF]

iScience
Charlanne LM, Sente B, Vetter SG, Einwaller J, Painer-Gigler J, Bergouignan A, Zahariev A, Gilbert C, Giroud S.   +8 more
europepmc   +1 more source

Cross-reactive human antibody responses to H9N2 influenza virus, New York, United States, 2025. [PDF]

Euro Surveill
Singh G, Bhavsar D, Ferreri LM, Nardulli JR, Gleason C, Lyttle N, Chen Y, Lowen AC, Simon V, Krammer F.   +9 more
europepmc   +1 more source

Genomic evolution of SARS-CoV-2 delta variants pre- and post-omicron emergence using alignment-free machine learning models. [PDF]

PLoS One
Sankar S, Anandharaman K, Selvam P, Jayaraman A, Jayakumar D, Balakrishnan P, Larsson M, Velu V, Raju S, Shankar EM.   +9 more
europepmc   +1 more source

Biogenic Silica Nanoparticles Enhance <i>Beauveria bassiana</i> Bioavailability and Efficacy for Sustainable Pest Control. [PDF]

ACS Omega
Harada LK, Guilger-Casagrande M, Germano-Costa T, Bilesky-José N, Polanczyk RA, Gonçalves KC, da Silva PG, Silva E Silva JV, Prado RM, Fraceto LF, Lima R.   +10 more
europepmc   +1 more source