Results 81 to 90 of about 6,205,342 (287)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

ADIPOSE-DERIVED MULTIPOTENT STROMAL CELLS IN REGENERATIVE MEDICINE [PDF]

, 2020
Beside adipose tissue had been considered a discard product for many years, recently its role as regenerative agent has been widely recognized. Adipose tissue is a connective tissue constituted of adipocytes interspersed with collagen fibers and stromal ...
Dai Pre' Elena
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Seletividade de herbicidas residuais ao feijão-comum durante o período inicial da fase vegetativa Selectivity of residual herbicides to common bean during the early period of the vegetative phase

Planta Daninha, 2013
Avaliou-se neste trabalho a seletividade de herbicidas residuais, aplicados em doses crescentes, na condição de pré-emergência, sobre o crescimento do feijão-comum (Phaseolus vulgaris) durante o início da fase vegetativa da cultura.
A. Kalsing, R.A. Vidal
doaj  

Herbicide Screening and Application Method Development for Sustainable Weed Management in Tagetes erecta L. Fields

Plants
Marigold (Tagetes erecta L.), a crop of significant medicinal, ornamental, and economic value, faces severe industrialization challenges due to weed-induced yield losses (up to 60%).
Yiping Zhang, Dongyan Feng, Chengcheng Jia, Wangqi Huang, Feng Xu, Yalian Jiang, Junhong Huang, Ye Li, Jihua Wang, Dongsheng Tang   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Response of Wheat to Pre-Emergence and Early Post-Emergence Herbicides

Agronomy
A two-year field experiment was conducted in two consecutive seasons to evaluate the response of wheat to pre-emergence (PRE) and early post-emergence (EPOST) herbicides.
Thomas Gitsopoulos, Ioannis Georgoulas, Despoina Botsoglou, Eirini Vazanelli   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Efeito residual de herbicidas em pré-plantio do feijoeiro, em dois sistemas de aplicação em plantio direto e sua viabilidade econômica Economic viability of residual herbicides in dry bean pre-planting under two aplication methods

Planta Daninha, 2004
A pesquisa teve como objetivo avaliar a eficiência e a viabilidade econômica de controle de plantas daninhas com alguns herbicidas residuais (registrados ou não), aplicados em pré-plantio na cultura do feijoeiro.
T. Cobucci, C.M.O. Portela, W. Silva, A. Neto Monteiro   +3 more
doaj   +1 more source