Results 141 to 150 of about 6,205,342 (287)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Tolerance of lentils to pre-emergence herbicides
Proceedings of the New Zealand Weed and Pest Control Conference, 1987 J.H.B. Butler, R.T. Alexander
openaire +2 more sources
The Ontology of Complex Systems: Wimsatt on Emergence
openThis dissertation aims to offer a perspective on Wimsatt's work, emphasizing its originality in addressing ontological issues related to emergence. The first section provides a concise overview of Wilson's concept of Weak Emergence, serving as common
LONGATO, ORSO LODOVICO
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BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Enhancing Plantation Productivity: A Screen-house Investigation into the Impact of Indaziflam on Amaranthus, Maize, Melon, and Tomato in Intercropping Systems [PDF]
Tunisian Journal of Plant ProtectionImomoh, I.J., Ayodele, O.P., and Ikuenobe, C.E. 2024. Enhancing plantation productivity: A screen-house investigation into the impact of indaziflam on amaranthus,maize, melon, and tomato in intercropping systems.
Isesele John Imomoh +2 more
doaj
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Emergence in organizations: The reflexive turn
, 2010 In this paper we explore the role and meaning of the concept of emergence in the study of organizations. A brief recount of the history of the concept of emergence illustrates a general failure to distinguish between the mechanisms of emergence present ...
Kay, R, Goldspink, C
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