Results 101 to 110 of about 3,065,240 (256)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Developing a conceptual model for exploring emergence
, 2006 Emergence is a fundamental property of complex systems and can be thought of as a new property or behaviour which appears due to non-linear interactions within the system; emergence may be considered to be the 'product' or by-product of the system.
McDonald, D.M., Weir, G.R.S.
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) caused by application of pre-emergence herbicide
, 2013 The critical time for weed removal (CTWR) is a period in the crop growth cycle when weed control must be initiated to prevent yield losses. Knowing the CTWR is useful for making decisions about the timing of weed control and in achieving efficient ...
Glamočlija, Đorđe +14 more
core +1 more source
Unhealthy landscapes: Policy recommendations on land use change and infectious disease emergence. [PDF]
, 2004 Anthropogenic land use changes drive a range of infectious disease outbreaks and emergence events and modify the transmission of endemic infections.
Patz, Jonathan A +22 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Neutral Emergence and Coarse Graining Cellular Automata [PDF]
, 2010 Emergent systems are often thought of as special, and are often linked to desirable properties like robustness, fault tolerance and adaptability. But, though not well understood, emergence is not a magical, unfathomable property.
Weeks, Andrew
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fundamental and Applied AgricultureTank-mixture of two or more chemical groups of either pre- or post-emergence herbicide might play a vital role to manage weeds of a diversified community more effectively than their single or sequential application.
A K M Mominul Islam +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pre-emergence herbicides affect seedling emergence of tropical forest tree species
, 2017 Testing techniques to reduce weed infestation is a crucial step in developing direct tree seeding systems. The use of pre-emergence herbicides may be an alternative to manual weeding techniques, but so far, information on how they affect the seeds of ...
Engel, Vera Lex +3 more
core +1 more source