Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization. Owing to this ‘protective’ effect on the nociceptive system, pre-emptive analgesia has the potential to be ...
JørgenB. Dahl +2 more
exaly +14 more sources
Why do hegemonic powers appear to have so few viable policy levers with which to cope with their fears of decline, and often adopt policies that are least well-suited, if not antithetical to the task?
Robert Denemark
doaj +3 more sources
Improving the effect and efficiency of FMD control by enlarging protection or surveillance zone [PDF]
An epidemic of foot-and-mouth disease (FMD) in a FMD-free country with large exports of livestock and livestock products would result in profound economic damage. This could be reduced by rapid and efficient control of the disease spread.
Tariq eHalasa +2 more
doaj +4 more sources
Pre-emptive pharmacogenetic testing in Italy: a review of evidence and multidisciplinary consensus on key priorities for implementation [PDF]
BackgroundPre-emptive pharmacogenetic (PGx) testing involves identifying genetic variants associated with drug response before prescribing medication, with the aim of guiding drug selection or dosing to reduce adverse reactions and improve outcomes ...
Angelica Valz Gris +16 more
doaj +2 more sources
Minimizing bleeding risks during gastric neuroendocrine tumor endoscopic submucosal dissection by pre-emptive EUS-guided epinephrine injection [PDF]
Background and Aims: Gastric neuroendocrine tumors (NETs), although rare, are highly vascular subepithelial lesions that can pose significant bleeding risks during endoscopic submucosal dissection (ESD).
Radhika Chavan, MD, DNB, FISG, FASGE +6 more
doaj +2 more sources
Living Donation and Pre-Emptive Transplantation Are More Important Than HLA Matching in Pediatric Kidney Transplantation: Results From a 33-Year Comparative OPTN Study [PDF]
Poorly HLA matched transplants have poorer long-term outcomes, however it is unclear whether living donation or pre-emptive transplantation can counteract the effects of HLA mismatches.
Alicia Paessler +11 more
doaj +2 more sources
Pre‐Emptive Amlodipine for FOLFIRINOX‐Induced Hypertensive Crises Without Primary Hypertension: A Novel Chronotherapeutic Strategy [PDF]
FOLFIRINOX remains a cornerstone therapy for advanced pancreatic ductal adenocarcinoma (PDAC), but its toxicity profile extends beyond myelosuppression and neuropathy to include even rarer complications such as treatment‐associated hypertension. Infusion‐
Manas Pustake +4 more
doaj +2 more sources
Empirical versus pre-emptive antifungal therapies for invasive fungal infections in critically ill patients [PDF]
Background The initiation strategy of antifungal therapy (AT) is among the most discussed practices for patients vulnerable to invasive fungal infections (IFI).
Hong Tham Pham +4 more
doaj +2 more sources
Estimation of the benefit from pre‐emptive genotyping based on the nationwide cohort data in South Korea [PDF]
Genetic variants affect drug responses, making pre‐emptive genotyping crucial for averting serious adverse events (SAEs) and treatment failure. However, assessing the benefits of pre‐emptive genotyping based on genetic distribution, drug exposure, and ...
Ki Young Huh +6 more
doaj +2 more sources
Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple resection (SPARROW): a study protocol for a multicentre, open-label, randomised controlled trial [PDF]
Background Consensus and evidence on the impact of pre-emptive antibiotic treatment after pancreatoduodenectomy is lacking, which is reflected by contradictory recommendations in (inter)national guidelines and current clinical practice.
D. H. M. Droogh +18 more
doaj +2 more sources

