Results 161 to 170 of about 6,804,228 (211)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Prospective HIV RNA screening with long-acting cabotegravir pre-exposure prophylaxis in HPTN 083. [PDF]

Clin Infect Dis
Landovitz RJ, Fogel JM, Gao F, Hanscom B, Piwowar-Manning E, Moser A, Marzinke MA, Cyktor J, Seisa M, Halvas EK, Kofron R, Jennings A, Clement M, Viet Tran H, Gaur A, Fichtenbaum CJ, Asmelash A, Soto-Torres L, Rooney JF, Rinehart AR, Cohen MS, Grinsztejn B, Eshleman SH.   +22 more
europepmc   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Pre-exposure Prophylaxis Outcomes in High-Risk Individuals in Saudi Arabia: A 48-Week Observational Cohort Study. [PDF]

Cureus
Alsaeed A.
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Persistence on Oral HIV Pre-Exposure Prophylaxis Among Key Populations at a Centre in Buenos Aires: A Survival Analysis of a Real-World Cohort. [PDF]

J Int AIDS Soc
Garcia JL, Salusso D, Mernies G, Sandoval MM, Petriglieri C, Bilbao F, Parera D, Perez C, Duran A, Aristegui I, Figueroa MI, Cesar C.   +11 more
europepmc   +1 more source

Safety and Efficacy of the Versius Surgical System in Transoral Robotic Surgery: A Prospective Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the safety and feasibility of the Versius surgical robotic system for transoral robotic surgery in benign and malignant head and neck indications. Study Design Open‐label, prospective, single‐arm, phase II clinical trial. Setting Liverpool Head and Neck Centre, United Kingdom. Methods Between December 2023 and March 2025,
Jason C. Fleming, Katharine Davies, Christopher Loh, Mark Wilkie, Xander Lawson, Saul Truckle, James Constable, Jennifer Gwinnutt, Jennifer Rodrigues, Paul Banks, Zoe Mellor, Terry M. Jones   +11 more
wiley   +1 more source

Drivers of Vertical HIV Transmission in Sub-Saharan Africa and the Impact and Cost-Effectiveness of Targeted and Universal Lenacapavir Pre-Exposure Prophylaxis. [PDF]

J Int AIDS Soc
Yakusik A, Walters MK, Mattur D, Brar S, Johnson LF, Meyer-Rath G, Jamieson L, Mushavi A, Stover J, Mahy M.   +9 more
europepmc   +1 more source

Clinical Effectiveness of Sialendoscopy in Radioactive Iodine‐induced Sialadenitis: A Systematic Review and Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To systematically review and synthesize outcomes following sialendoscopy in patients with salivary gland dysfunction and a history of radioactive iodine (RAI). Data Sources A comprehensive search of Medline, Embase, and Cochrane Library was conducted from database inception through December 26, 2025.
Michal Kulasek, Alexander C. Moise, Sam J. Daniel   +2 more
wiley   +1 more source

Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men. [PDF]

Nat Commun
Iannuzzi S, Müller M, Yu Y, Zhang L, Hendrix CW, Bies RR, von Kleist M.   +6 more
europepmc   +1 more source