Results 61 to 70 of about 370,245 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Structural improvement of a mobile device for pre-heated treatment of vegetable raw materials

Eastern-European Journal of Enterprise Technologies
The object of this study is the heat treatment of multicomponent masses, for example, Jerusalem artichoke, pumpkin, and black chokeberry, during thickening and drying in an improved mobile functional apparatus for preliminary heat operations. The engineering solution is aimed at the implementation of resource-saving preliminary thermal operations of ...
Andrii Zahorulko, Iryna Voronenko, Lyudmila Chuiko, Nataliia Tytarenko, Eldar Ibaiev, Alla Solomon, Oksana Skoromna, Maksym Prykhodko   +7 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effect of Pre - Heat- Treatment on Austenite Grain Size of Steel 508-3

Teshugang, 2013
Test steel 508-3 (/% : 0. 19C, 0. 26Si, 1.48Mn, 0. 009P, 0. 007S, 0. 78Ni, 0. 50Mo, 0.003Al) is melted by a vacuum induction furnace and cast to 50 kg ingot, forged at 1 150 to Φ16 mm bar, end forging ≥900℃.The effect of normalizing temperature (900 ~ 1 ...
何西扣, 刘正东, 林肇杰
doaj  

Effects of passive heat stress and recovery on human cognitive function: An ERP study.

PLoS ONE, 2021
Using event-related potentials (ERPs), we investigated the effects of passive heat stress and recovery on the human cognitive function with Flanker tasks, involving congruent and incongruent stimuli.
Hiroki Nakata, Ryusuke Kakigi, Manabu Shibasaki   +2 more
doaj   +1 more source

Enhancing The Formability of SS304 in ISF via Pre-Heating Treatment Strategies

International Journal of Innovation in Mechanical Engineering and Advanced Materials
The increasing demand for lightweight yet high-strength components in the automotive and aerospace industries has accelerated interest in Incremental Sheet Forming (ISF) as a flexible, dieless, and cost-effective manufacturing process, particularly for low-volume and customized production.
Muhammad Aqib Raza Shah, Agung Shamsuddin Saragih   +1 more
openaire   +1 more source

Effects of Platform Pre-Heating and Thermal-Treatment Strategies on Properties of AlSi10Mg Alloy Processed by Selective Laser Melting [PDF]

Metals, 2018
The AlSi10Mg alloy was processed by selective laser melting using both hot- and cold-build platforms. The investigation was aimed at defining suitable platform pre-heating and post-process thermal treatment strategies, taking into consideration the peculiar microstructures generated. Microstructural analyses, differential scanning calorimetry, and high-
Riccardo Casati, Milad Hamidi Nasab, Mauro Coduri, Valeria Tirelli, Maurizio Vedani   +4 more
openaire   +5 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source