Results 171 to 180 of about 240,689 (215)

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Emergency-Care Utilisation During Two Healthcare Crises in South Korea: A Single-Centre Comparison of Calendar-Aligned 32-Week Windows. [PDF]

J Clin Med
Park C, Lee KH, Kim OH, Kim SJ.
europepmc   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

Remote patient monitoring and caregiver education for children with failure to thrive: a quasi-experimental study. [PDF]

Front Pediatr
Tisdale J, Newbaker KB, Green JB, QaDan R, Hasan MR, Kuiper LB, Collado C, Nahar VK, Dear JL.   +8 more
europepmc   +1 more source

Synergistic Mechano‐Fluidic Self‐Fusion of Poly(Vinyl Alcohol)‐Modified Liquid‐Metal Particles for Post‐Treatment‐Free Soft Electronics

Advanced Science, EarlyView.
Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook, Sangwon Kim, Chansoo Kim, Minkyong Kang, Yurim Lee, Mido Kim, Kijun Park, Seung Yeop Han, Seung‐Woo Cho, Gun‐Hee Lee, Kayoung Son, Hanbit Jang, Tae Young Kim, Jungmok Seo   +13 more
wiley   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Prehospital Emergency Care for Traumatic Brain Injury Patients in Hanoi: A Multicenter Study of Outcomes and Quality of Care. [PDF]

Emerg Med Australas
Hoang BH, Tran TL, Nguyen T, Luong QC, Dinh MM.   +4 more
europepmc   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source