Results 161 to 170 of about 453,474 (372)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Disk-locking Regulates Stellar Rotation in Young Clusters: Insights from NGC 2264

The Astrophysical Journal
Many young clusters possess extended main sequences, a phenomenon commonly ascribed to stellar rotation. However, the mechanism behind their very wide stellar rotation distributions remains unclear.
Yutian Bu, Chenyu He, Min Fang, Chengyuan Li   +3 more
doaj   +1 more source

Magnetism, rotation and accretion in Herbig Ae-Be stars

, 2007
Studies of stellar magnetism at the pre-main sequence phase can provide important new insights into the detailed physics of the late stages of star formation, and into the observed properties of main sequence stars.
Blondel, Bouret, C. Catala, C. Folsom, Catala, Catala, Catala, Catala, Catala, Collier Cameron, E. Alecian, G.A. Wade, Hubrig, J. Grunhut, J.-C. Bouret, J.-F. Donati, J.D. Landstreet, Landi, Lignières, Morel, Natta, P. Petit, S. Bagnulo, Stepień, Stepień, T. Boehm, Thé, Wade   +27 more
core   +1 more source

Spatial distribution of pre-main sequence stars in Taurus.

, 1993
We derive characteristic properties of the nonrandom spatial distribution of pre-main-sequence stars in the Taurus-Auriga molecular cloud by applying several different statistical techniques.
M. Gómez, L. Hartmann, S. Kenyon, R. Hewett   +3 more
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Gaia23bab: A New EXor

The Astrophysical Journal
On 2023 March 6, the Gaia telescope alerted a 2 mag burst from Gaia23bab, a young stellar object in the Galactic plane. We observed Gaia23bab with the Large Binocular Telescope obtaining optical and near-infrared spectra close in time to the peak of the ...
T. Giannini, E. Schisano, B. Nisini, P. Ábrahám, S. Antoniucci, K. Biazzo, F. Cruz-Sáenz de Miera, E. Fiorellino, M. Gangi, A. Kóspál, M. Kuhn, E. Marini, Z. Nagy, D. Paris   +13 more
doaj   +1 more source

Magnetic Bp and Ap stars in the H-R diagram [PDF]

arXiv, 1998
The positions in the H-R diagram of strongly magnetic Ap and Bp stars are compared with those of normal main sequence stars of types B7 to F2, with a view to investigating possible differences in evolutionary status between magnetic and non-magnetic stars.
arxiv  

A high fraction of Be stars in young massive clusters: evidence for a large population of near-critically rotating stars [PDF]

, 2016
Recent photometric analysis of the colour-magnitude diagrams (CMDs) of young massive clusters (YMCs) have found evidence for splitting in the main sequence and extended main sequence turn-offs, both of which have been suggested to be caused by stellar rotation.
arxiv   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Haro 5-2: A New Pre-main-sequence Quadruple Stellar System

The Astronomical Journal
We have discovered that the H α emission-line star Haro 5-2, located in the 3–6 Myr old Ori OB1b association, is a young quadruple system. The system has a 2+2 configuration, with an outer separation of 2.″6 and with resolved subarcsecond inner binary ...
Bo Reipurth, C. Briceño, T. R. Geballe, C. Baranec, S. Mikkola, A. M. Cody, M. S. Connelley, C. Flores, B. A. Skiff, J. D. Armstrong, N. M. Law, R. Riddle   +11 more
doaj   +1 more source