Results 221 to 230 of about 453,474 (372)
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co‐morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox+3 more
wiley +1 more source
Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter+3 more
wiley +1 more source
Resolving Twin Jets and Twin Disks with JWST and ALMA: The Young WL 20 Multiple System
We report the discovery of jets emanating from pre-main-sequence objects exclusively at mid-infrared wavelengths, enabled by the superb sensitivity of JWST’s Mid-Infrared Instrument Medium-Resolution Spectrometer. These jets are observed only in lines of
Mary Barsony+4 more
doaj +1 more source
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi+4 more
wiley +1 more source
Regulating Protein Immobilization During Cell‐Free Protein Synthesis in Hyaluronan Microgels
Bifunctional microgels carrying a linear DNA template and Ni2+‐activated NTA moieties are used as platform for cell‐free protein synthesis and in situ protein immobilization. By varying the concentration of NTA moieties in the microgels, the amount of GFP‐His immobilized inside the microgel and released to the microgel environment can be regulated ...
Anika Kaufmann+2 more
wiley +1 more source
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André+3 more
wiley +1 more source
This manuscript presents advances in digital transformation within materials science and engineering, emphasizing the role of the MaterialDigital Initiative. By testing and applying concepts such as ontologies, knowledge graphs, and integrated workflows, it promotes semantic interoperability and data‐driven innovation. The article reviews collaborative
Bernd Bayerlein+44 more
wiley +1 more source
KupferDigital: Ontology‐Based Digital Representation for the Copper Life Cycle
It is demonstrated how data from different stages in the life cycle of a copper product can be stored in an ontology‐based data space. In order to showcase the methods and tools used in the project, four use cases are presented that show how data from different sources can be semantically described and queried from a shared data space.
Miriam Eisenbart+18 more
wiley +1 more source
Pre-main-sequence stars in the young open cluster NGC 1893 [PDF]
A. Marco, I. Negueruela
openalex +1 more source