Results 111 to 120 of about 2,816,416 (315)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Glucose Content of Sago Waste After Chloride Acid Pre- Treatment Hydrolysis For Bioethanol Production [PDF]

open access: yes, 2015
Indonesia is a country with abundant agricultural biological resources. One of the plants as a biological source is sago. Sago processing wastes such as bark and waste about 72%.
A, Agustina LN   +6 more
core  

Effect of sustained attention on Early Start Denver Model outcomes [PDF]

open access: yes, 2020
Introduction: There is very little research on the use of sustained attention as an outcome predictor for the Early Start Denver Model (ESDM). We hypothesized that a child’s level of sustained attention prior to therapy will correlate with positive ESDM ...
McLeod, Katherine, Vivanti, PhD, Giacomo
core   +1 more source

β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia [PDF]

open access: yes, 2017
β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects
Domondon, Philip   +7 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Antibiofilm Effect of DNase against Single and Mixed Species Biofilm

open access: yesFoods, 2018
Biofilms are aggregates of microorganisms that coexist in socially coordinated micro-niche in a self-produced polymeric matrix on pre-conditioned surfaces. The biofilm matrix reduces the efficacy of antibiofilm strategies.
Komal Sharma, Ankita Pagedar Singh
doaj   +1 more source

Pre-treatment of Used-Cooking Oil as Feed Stocks of Biodiesel Production by Using Activated Carbon and Clay Minerals [PDF]

open access: yes, 2014
Many low-cost feedstock i.e. used-cooking oil (UCO) for the production of biodiesel fuel (BDF) has contained a large amount of water and high proportion of free fatty acids (FFAs). Therefore, a pre-treatment process to reduce the water content (
Hartono, P. (Puji)   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A Conversation on Data Mining Strategies in LC-MS Untargeted Metabolomics: Pre-Processing and Pre-Treatment Steps

open access: yesMetabolites, 2016
Untargeted metabolomic studies generate information-rich, high-dimensional, and complex datasets that remain challenging to handle and fully exploit. Despite the remarkable progress in the development of tools and algorithms, the “exhaustive” extraction ...
Fidele Tugizimana   +3 more
doaj   +1 more source

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