Results 171 to 180 of about 9,867,009 (304)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Pre-trial Investigation of Criminal Offences Related to Domestic Violence

Дисертаційне дослідження присвячене проблемним аспектам здійснення досудового розслідування кримінальних правопорушень, пов’язаних з домашнім насильством.
Hontarenko, V. P., Гонтаренко, В. П.   +1 more
core   +1 more source

Distinguishing prolonged grief and mental well-being after homicidal loss: a longitudinal factor analytic study in the context of a criminal trial. [PDF]

Eur J Psychotraumatol
Nijborg LCJ, Westerhof GJ, Kunst MJJ, de Keijser J, Lenferink LIM.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Xenobiotic transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model: A pilot study. [PDF]

Pregnancy (Hoboken)
Loza A, Lotfi A, Wagner R, Aksenov A, Shields A.   +4 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Pre-treatment polyfunctionality percentage (PFA) of CD8+ T cells is associated with development of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICIs). [PDF]

Neoplasia
Thompson J, Palen K, Menon S, Chen HZ, Kearl T.   +4 more
europepmc   +1 more source

Issues related to the use of statements given during pre-trial investigation in criminal proceedings. [PDF]

This Master‘s thesis analyses the institution of reading out (publicising) the testimonies given during a pre-trial investigation during a trial. The synergy between legal science and cognitive psychology is used to assess the influence of testimonies ...
Samuitytė, Irmantė,
core  

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Influence of hearing in the non-implanted ear and age on long-term speech recognition benefit for adult cochlear implant users with asymmetric hearing loss. [PDF]

Front Neurosci
Mihailescu S, Scharf SP, Thompson NJ, Richter ME, Dedmon MM, Sloop AD, Brown KD, Dillon MT.   +7 more
europepmc   +1 more source