Results 301 to 310 of about 73,384 (360)

Conversion of pyridoxal to pyridoxamine with NH3 and H2 on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

open access: yesThe FEBS Journal, EarlyView.
Recent studies show that Ni0 catalyzes amino acid synthesis from 2‐oxoacids via reductive amination. We show that the cofactor pyridoxal is reductively aminated to pyridoxamine, the NH2‐transferring intermediate of transaminations, with NH3 (~ 5 mm) and H2 (5 bar) on Ni0 catalysts within hours in water under serpentinizing hydrothermal vent conditions (
Manon Laura Schlikker   +7 more
wiley   +1 more source

Protometabolic functions of pyridoxal: A link between early amino acid synthesis and enzyme evolution

open access: yesThe FEBS Journal, EarlyView.
Schlikker et al. characterized the conversion of pyridoxal to pyridoxamine under conditions mimicking the ones likely existing at the origin of metabolism. These conditions triggered nitrogen incorporation into amino acids in solution before the origins of enzymes.
Mariarita Bertoldi, Gianluca Molla
wiley   +1 more source

Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care

open access: yesInternational Journal of Dermatology, EarlyView.
Unlocking longevity in aesthetic dermatology: epigenetics, aging, and personalized care. ABSTRACT The concept of aging has evolved from being primarily attributed to genetic factors to recognizing the critical role of epigenetic mechanisms. Recent advancements, such as epigenetic clocks, have provided tools to assess biological age and offer insights ...
Diala Haykal   +4 more
wiley   +1 more source

Functional Foods and Nutraceuticals in Irritable Bowel Syndrome. [PDF]

open access: yesJ Clin Med
Marasco G   +8 more
europepmc   +1 more source

Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Microbiotherapy has opened new avenues for managing dysbiosis‐related diseases. However, many studies did not cover all the necessary reporting items for microbiotherapy making the interpretation of results, safety assessment, technology extension, and even the transparency of legitimacy difficult. This project consisted of 2 phases. First, we
Faming Zhang   +22 more
wiley   +1 more source

Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).
Mei Luo   +4 more
wiley   +1 more source

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