Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Medicine, Duty and Disaster: The Lives and Last Hours of RMS Titanic's Surgeons. [PDF]
Ann Surg OpenMcKenna ME, Ross FL.
europepmc +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Delegated agency and moral responsibility in artificial intelligence. [PDF]
Front Artif IntellRadanliev P.
europepmc +1 more source
Anthroponyms in the Novel by Maryna Hrymych “Egoist” : Structural, Semantic and Functional Aspects
, 2017 Статтю присвячено дослідженню структурно-семантичних і функційних особливостей літературно-художніх антропонімів роману «Еґоїст» Марини Гримич; визначенню зв’язку з реальними постатями в українській історії як логічною основою для формування прецедентних
Бєляєва, Т. В. +1 more
core
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Desensitization With Imlifidase: Overcoming Immunological Barriers in Kidney Transplantation. [PDF]
Kidney MedHernández-Velasco PJ +6 more
europepmc +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Demographic and clinical characteristics of Guillain-Barré syndrome at Kenyatta National Hospital, Kenya. [PDF]
BMJ Neurol OpenMuindi SK, Onyango M, Masika MM.
europepmc +1 more source
Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution
BMEMat, EarlyView.The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez +6 more
wiley +1 more source