Results 101 to 110 of about 142,094 (323)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Depth Fluctuations of Mediterranean Outflow Water Along Its Northward Propagation During the Late Pleistocene

Geophysical Research Letters
Mediterranean Outflow Water (MOW) critically influences the Atlantic Meridional Overturning Circulation, yet its northward transport dynamics along the Iberian Margin remain unclear.
Xinyang Chen, Jiawang Wu, Xiaolei Pang, Haowen Dang, Lifeng Zhong, Jimin Yu, Christophe Colin, Zhifei Liu, Gert J. deLange, Stefanie Kaboth‐Bahr, Chuang Xuan, Hisashi Ikeda, Timothy D. Herbert, Huai‐Hsuan May Huang, Carlos A. Alvarez Zarikian, Fátima F. G. Abrantes, David A. Hodell   +16 more
doaj   +1 more source

Impact of eccentricity on regional aridity-humidity variations

地球与行星物理论评
Climatic aridity-humidity variations on orbital timescales are crucial for understanding the Earth's climate system response mechanisms. Investigating the relationship between orbital-scale eccentricity cycles and aridity-humidity changes helps clarify ...
Sunyi Dong, Qingqing Qiao, Gangqiang Li
doaj   +1 more source

PLANET: An ellipse fitting approach for simultaneous T1 and T2 mapping using phase‐cycled balanced steady‐state free precession

Magnetic Resonance in Medicine, 2017
To demonstrate the feasibility of a novel, ellipse fitting approach, named PLANET, for simultaneous estimation of relaxation times T1 and T2 from a single 3D phase‐cycled balanced steady‐state free precession (bSSFP) sequence.
Yulia Shcherbakova, C. V. D. van den Berg, C. Moonen, L. Bartels   +3 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Spin Precession and Avalanches [PDF]

Physical Review Letters, 2007
In many magnetic materials, spin dynamics at short times are dominated by precessional motion as damping is relatively small. In the limit of no damping and no thermal noise, we show that for a large enough initial instability, an avalanche can transition to an ergodic phase where the state is equivalent to one at finite temperature, often above that ...
Deutsch, J. M., Berger, A.
openaire   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Effect of rotation and magnetic field in the gyroscopic precession around a neutron star

European Physical Journal C: Particles and Fields, 2020
General relativistic effects are essential in defining the spacetime around massive astrophysical objects. The effects can be captured using a test gyro. If the gyro rotates at some fixed orbit around the star, then the gyro precession frequency captures
Kamal Krishna Nath, Ritam Mallick
doaj   +1 more source

Spectral dependence of photoinduced spin precession in DyFeO3

, 2011
Spin precession was nonthermally induced by an ultrashort laser pulse in orthoferrite DyFeO3 with a pump-probe technique. Both circularly and linearly polarized pulses led to spin precessions; these phenomena are interpreted as the inverse Faraday effect
A. K. Zvezdin, A. M. Balbashov, A. V. Zalesskii, B. A. Ivanov, E. A. Turov, H. P. J. Wijn, Kazuo Kuroda, L. D. Landau, Ryugo Iida, Takuya Satoh, Tsutomu Shimura, V. G. Baryakhtar, V. V. Eremenko, Yoshinori Tokura, Yusuke Tokunaga   +14 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source